FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979746473> ?p ?o ?g. }

• W1979746473 abstract "1 Chloramphenicol continues to be widely used in many parts of the world despite its known haematotoxicity. Until now, elucidation of the mechanisms involved and any attempt at amelioration of the toxic effects have been hampered by the lack of an animal model. 2 In this study neither acute nor chronic administration of chloramphenicol as its succinate ester in the drinking water produced anaemia in mice as assessed by changes in peripheral blood parameters. 3 Chloramphenicol could not be detected in the bone marrow when the antibiotic was administered either in the drinking water or by gavage, although it was detected in the serum. 4 In marrow taken from mice after chloramphenicol succinate administration and cultured in vitro, depression of the differentiation of immature committed erythroid progenitors occurred 15 min after administration of the antibiotic by gavage. However, recovery was beginning to occur at 48 h after administration of chloramphenicol succinate at 50 and 200 mg/kg and this was then followed by an `overshoot' response at the higher dose. A toxic effect was therefore achieved in the bone marrow but this was probably masked in the peripheral blood by enhanced proliferation. 5 Morphological evidence of apoptosis was seen in erythroid and myeloid precursors in mice treated with 200 mg/kg. 6 The data suggest that the effect of chloramphenicol was at the differentiation stage of the committed marrow progenitor cells rather than at the replication stage of the stem cells and therefore this response appears to mimic the reversible bone marrow depression seen in the treated patient." @default.
• W1979746473 created "2016-06-24" @default.
• W1979746473 creator A5010910451 @default.
• W1979746473 creator A5019834044 @default.
• W1979746473 creator A5022666165 @default.
• W1979746473 creator A5041009093 @default.
• W1979746473 creator A5077992513 @default.
• W1979746473 date "1998-01-01" @default.
• W1979746473 modified "2023-09-26" @default.
• W1979746473 title "The myelotoxicity of chloramphenicol: in vitro and in vivo studies: II: in vivo myelotoxicity in the B6C3F mouse" @default.
• W1979746473 cites W142053782 @default.
• W1979746473 cites W1900963430 @default.
• W1979746473 cites W1977897164 @default.
• W1979746473 cites W1984658535 @default.
• W1979746473 cites W1996744037 @default.
• W1979746473 cites W2000021071 @default.
• W1979746473 cites W2007224501 @default.
• W1979746473 cites W2009183764 @default.
• W1979746473 cites W2010607252 @default.
• W1979746473 cites W2033547254 @default.
• W1979746473 cites W2038377343 @default.
• W1979746473 cites W2043761464 @default.
• W1979746473 cites W2045052987 @default.
• W1979746473 cites W2052853635 @default.
• W1979746473 cites W2059513181 @default.
• W1979746473 cites W2062626739 @default.
• W1979746473 cites W2067807857 @default.
• W1979746473 cites W2068164716 @default.
• W1979746473 cites W2068499309 @default.
• W1979746473 cites W2080324155 @default.
• W1979746473 cites W2094809074 @default.
• W1979746473 cites W2094843000 @default.
• W1979746473 cites W2339322825 @default.
• W1979746473 cites W2400385801 @default.
• W1979746473 cites W2414255864 @default.
• W1979746473 cites W4253970653 @default.
• W1979746473 cites W43183315 @default.
• W1979746473 doi "https://doi.org/10.1177/096032719801700102" @default.
• W1979746473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9491332" @default.
• W1979746473 hasPublicationYear "1998" @default.
• W1979746473 type Work @default.
• W1979746473 sameAs 1979746473 @default.
• W1979746473 citedByCount "13" @default.
• W1979746473 countsByYear W19797464732015 @default.
• W1979746473 countsByYear W19797464732019 @default.
• W1979746473 countsByYear W19797464732022 @default.
• W1979746473 countsByYear W19797464732023 @default.
• W1979746473 crossrefType "journal-article" @default.
• W1979746473 hasAuthorship W1979746473A5010910451 @default.
• W1979746473 hasAuthorship W1979746473A5019834044 @default.
• W1979746473 hasAuthorship W1979746473A5022666165 @default.
• W1979746473 hasAuthorship W1979746473A5041009093 @default.
• W1979746473 hasAuthorship W1979746473A5077992513 @default.
• W1979746473 hasConcept C126322002 @default.
• W1979746473 hasConcept C150903083 @default.
• W1979746473 hasConcept C201750760 @default.
• W1979746473 hasConcept C202751555 @default.
• W1979746473 hasConcept C203014093 @default.
• W1979746473 hasConcept C207001950 @default.
• W1979746473 hasConcept C2778473333 @default.
• W1979746473 hasConcept C2780007613 @default.
• W1979746473 hasConcept C28328180 @default.
• W1979746473 hasConcept C29730261 @default.
• W1979746473 hasConcept C501593827 @default.
• W1979746473 hasConcept C55493867 @default.
• W1979746473 hasConcept C71924100 @default.
• W1979746473 hasConcept C86803240 @default.
• W1979746473 hasConcept C89423630 @default.
• W1979746473 hasConcept C95444343 @default.
• W1979746473 hasConcept C98274493 @default.
• W1979746473 hasConceptScore W1979746473C126322002 @default.
• W1979746473 hasConceptScore W1979746473C150903083 @default.
• W1979746473 hasConceptScore W1979746473C201750760 @default.
• W1979746473 hasConceptScore W1979746473C202751555 @default.
• W1979746473 hasConceptScore W1979746473C203014093 @default.
• W1979746473 hasConceptScore W1979746473C207001950 @default.
• W1979746473 hasConceptScore W1979746473C2778473333 @default.
• W1979746473 hasConceptScore W1979746473C2780007613 @default.
• W1979746473 hasConceptScore W1979746473C28328180 @default.
• W1979746473 hasConceptScore W1979746473C29730261 @default.
• W1979746473 hasConceptScore W1979746473C501593827 @default.
• W1979746473 hasConceptScore W1979746473C55493867 @default.
• W1979746473 hasConceptScore W1979746473C71924100 @default.
• W1979746473 hasConceptScore W1979746473C86803240 @default.
• W1979746473 hasConceptScore W1979746473C89423630 @default.
• W1979746473 hasConceptScore W1979746473C95444343 @default.
• W1979746473 hasConceptScore W1979746473C98274493 @default.
• W1979746473 hasLocation W19797464731 @default.
• W1979746473 hasLocation W19797464732 @default.
• W1979746473 hasOpenAccess W1979746473 @default.
• W1979746473 hasPrimaryLocation W19797464731 @default.
• W1979746473 hasRelatedWork W2008509377 @default.
• W1979746473 hasRelatedWork W2079763637 @default.
• W1979746473 hasRelatedWork W2085312856 @default.
• W1979746473 hasRelatedWork W2121675907 @default.
• W1979746473 hasRelatedWork W2409112722 @default.
• W1979746473 hasRelatedWork W2416980524 @default.
• W1979746473 hasRelatedWork W2417445485 @default.
• W1979746473 hasRelatedWork W2796160847 @default.
• W1979746473 hasRelatedWork W2886928388 @default.

• next