FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997253433> ?p ?o ?g. }

• W1997253433 endingPage "239" @default.
• W1997253433 startingPage "231" @default.
• W1997253433 abstract "The generation of hydroxyl radicals (.OH) from the reaction of Cu(II) complexes with biological reductants such as ascorbic acid, glutathione, acetylcysteine, and hydroquinone was confirmed by spin-trapping experiments using electron spin resonance (ESR). The following Cu(II) complexes were used: Cu(II)-(CyHH)2 (CyHH, cyclo(L-histidyl-L-histidyl)), Cu(II)(OP)2 (OP, o-phenanthroline), Cu(II)(HGG) (HGG, L-histidyl-glycylglycine), and Cu(II)(en)2 (en, ethylenediamine). The methyl radical adduct of alpha-(pyridyl-4-N-oxide)-N-tert-butylnitrone (POBN-CH3) was obtained from the reaction of ascorbic acid with all Cu(II) complexes used here in the presence of a spin trap, POBN, and dimethyl sulfoxide, indicating the generation of .OH. Glutathione, N-acetylcysteine, and hydroquinone reacted with both Cu(II)(CyHH)2 and Cu(II)(OP)2 to generate POBN-CH3, while these reductants did not react with either Cu(II)(HGG) or Cu(II)(en)2. Interestingly, the formation of POBN-CH3 in the reaction of Cu(II)-(CyHH)2 with glutathione or N-acetylcysteine was found only at a Cu(II)(CyHH)2/glutathione or Cu(II)(CyHH)2/N-acetylcysteine ratio of 1. The DNA strand scission caused by reaction mixtures of Cu(II) complexes with reductants was investigated under the same conditions as the ESR spin-trapping experiments. Addition of ascorbic acid to mixtures of these four Cu(II) complexes and DNA resulted in DNA strand breakage. Hydroquinone plus Cu(II)(CyHH)2 also caused DNA strand scission. In addition, DNA strand breakage was observed with the reaction of Cu(II)(OP)2 with glutathione, N-acetylcysteine, and hydroquinone. In contrast, reaction mixtures of glutathione, N-acetylcysteine, or hydroquinone with Cu(II)-(HGG) or Cu(II)(en)2 did not cause DNA strand scission within the concentration range used. The results obtained here suggest that there is a good correlation between POBN-CH3 formation and DNA strand scission. Thus, DNA strand scission may be caused by .OH generated from the reaction of some Cu(II) complexes with biological reductants under aerobic conditions. Since ascorbic acid, glutathione, and N-acetylcysteine are present in living cells, some Cu(II) complexes may be capable of initiating DNA damage in the presence of these reductants." @default.
• W1997253433 created "2016-06-24" @default.
• W1997253433 creator A5003554332 @default.
• W1997253433 creator A5019458192 @default.
• W1997253433 creator A5048193035 @default.
• W1997253433 creator A5064622391 @default.
• W1997253433 date "1998-09-01" @default.
• W1997253433 modified "2023-09-26" @default.
• W1997253433 title "Reactive Oxygen Species Generated from the Reaction of Copper(II) Complexes with Biological Reductants Cause DNA Strand Scission" @default.
• W1997253433 cites W1734082729 @default.
• W1997253433 cites W1834172208 @default.
• W1997253433 cites W1971748722 @default.
• W1997253433 cites W1978910143 @default.
• W1997253433 cites W1996454694 @default.
• W1997253433 cites W1998703766 @default.
• W1997253433 cites W2002306720 @default.
• W1997253433 cites W2003296927 @default.
• W1997253433 cites W2012522878 @default.
• W1997253433 cites W2017500410 @default.
• W1997253433 cites W2024921655 @default.
• W1997253433 cites W2035326736 @default.
• W1997253433 cites W2036772991 @default.
• W1997253433 cites W2037347849 @default.
• W1997253433 cites W2053145973 @default.
• W1997253433 cites W2057891192 @default.
• W1997253433 cites W2068122914 @default.
• W1997253433 cites W2093371363 @default.
• W1997253433 cites W2093436200 @default.
• W1997253433 cites W2114780443 @default.
• W1997253433 cites W2123411694 @default.
• W1997253433 cites W2131030226 @default.
• W1997253433 cites W2336653108 @default.
• W1997253433 cites W2952927212 @default.
• W1997253433 cites W4236399409 @default.
• W1997253433 cites W957374447 @default.
• W1997253433 doi "https://doi.org/10.1006/abbi.1998.0811" @default.
• W1997253433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9735163" @default.
• W1997253433 hasPublicationYear "1998" @default.
• W1997253433 type Work @default.
• W1997253433 sameAs 1997253433 @default.
• W1997253433 citedByCount "68" @default.
• W1997253433 countsByYear W19972534332012 @default.
• W1997253433 countsByYear W19972534332013 @default.
• W1997253433 countsByYear W19972534332014 @default.
• W1997253433 countsByYear W19972534332015 @default.
• W1997253433 countsByYear W19972534332016 @default.
• W1997253433 countsByYear W19972534332017 @default.
• W1997253433 countsByYear W19972534332018 @default.
• W1997253433 countsByYear W19972534332019 @default.
• W1997253433 countsByYear W19972534332020 @default.
• W1997253433 countsByYear W19972534332021 @default.
• W1997253433 countsByYear W19972534332023 @default.
• W1997253433 crossrefType "journal-article" @default.
• W1997253433 hasAuthorship W1997253433A5003554332 @default.
• W1997253433 hasAuthorship W1997253433A5019458192 @default.
• W1997253433 hasAuthorship W1997253433A5048193035 @default.
• W1997253433 hasAuthorship W1997253433A5064622391 @default.
• W1997253433 hasConcept C108204754 @default.
• W1997253433 hasConcept C121332964 @default.
• W1997253433 hasConcept C139066938 @default.
• W1997253433 hasConcept C155647269 @default.
• W1997253433 hasConcept C161790260 @default.
• W1997253433 hasConcept C178790620 @default.
• W1997253433 hasConcept C179104552 @default.
• W1997253433 hasConcept C185592680 @default.
• W1997253433 hasConcept C187961010 @default.
• W1997253433 hasConcept C2777550763 @default.
• W1997253433 hasConcept C2778815226 @default.
• W1997253433 hasConcept C2780728571 @default.
• W1997253433 hasConcept C2986274086 @default.
• W1997253433 hasConcept C3044715 @default.
• W1997253433 hasConcept C31903555 @default.
• W1997253433 hasConcept C46141821 @default.
• W1997253433 hasConcept C544778455 @default.
• W1997253433 hasConcept C75473681 @default.
• W1997253433 hasConceptScore W1997253433C108204754 @default.
• W1997253433 hasConceptScore W1997253433C121332964 @default.
• W1997253433 hasConceptScore W1997253433C139066938 @default.
• W1997253433 hasConceptScore W1997253433C155647269 @default.
• W1997253433 hasConceptScore W1997253433C161790260 @default.
• W1997253433 hasConceptScore W1997253433C178790620 @default.
• W1997253433 hasConceptScore W1997253433C179104552 @default.
• W1997253433 hasConceptScore W1997253433C185592680 @default.
• W1997253433 hasConceptScore W1997253433C187961010 @default.
• W1997253433 hasConceptScore W1997253433C2777550763 @default.
• W1997253433 hasConceptScore W1997253433C2778815226 @default.
• W1997253433 hasConceptScore W1997253433C2780728571 @default.
• W1997253433 hasConceptScore W1997253433C2986274086 @default.
• W1997253433 hasConceptScore W1997253433C3044715 @default.
• W1997253433 hasConceptScore W1997253433C31903555 @default.
• W1997253433 hasConceptScore W1997253433C46141821 @default.
• W1997253433 hasConceptScore W1997253433C544778455 @default.
• W1997253433 hasConceptScore W1997253433C75473681 @default.
• W1997253433 hasIssue "2" @default.
• W1997253433 hasLocation W19972534331 @default.
• W1997253433 hasLocation W19972534332 @default.
• W1997253433 hasOpenAccess W1997253433 @default.
• W1997253433 hasPrimaryLocation W19972534331 @default.

• next