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- W2005915948 abstract "Recent work suggests that sex differences exist with regard to both the nature of neuroadaptation to alcohol during the development of dependence, and possibly, the neurodegenerative consequences of alcohol dependence. Volumetric studies in human samples show that females may demonstrate increased volumetric brain loss with equal or lesser dependence histories than males. Furthermore, animal studies demonstrate sex differences in glutamatergic, GABAergic, and adenosinergic receptor signaling and endocrine responses following prolonged alcohol exposure. These differences may influence the development of dependence, neuronal function, and viability, particularly during alcohol withdrawal. The present review discusses the current state of knowledge in this regard. It is concluded that there exists a clear need for a more extensive examination of potential sex differences in neurodegenerative consequences of alcohol dependence in men and women, particularly with regard to the role that alterations in amino acid signaling and hypothalamic–pituitary–adrenal axis function may play. Furthermore, we note the need for expanded examination of the unique role that alcohol withdrawal-associated neuronal activity may have in the development of dependence-associated neurotoxicity." @default.
- W2005915948 created "2016-06-24" @default.
- W2005915948 creator A5029744190 @default.
- W2005915948 creator A5038633022 @default.
- W2005915948 creator A5042992009 @default.
- W2005915948 creator A5052509069 @default.
- W2005915948 creator A5076674792 @default.
- W2005915948 date "2013-04-05" @default.
- W2005915948 modified "2023-10-06" @default.
- W2005915948 title "Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity" @default.
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