FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011424443> ?p ?o ?g. }

• W2011424443 endingPage "628" @default.
• W2011424443 startingPage "615" @default.
• W2011424443 abstract "Voltage-gated proton channels were studied under voltage clamp in excised, inside-out patches of human eosinophils, at various pHi with pHo 7.5 or 6.5 pipette solutions. H+ current fluctuations were observed consistently when the membrane was depolarized to voltages that activated H+ current. At pHi < or = 5.5 the variance increased nonmonotonically with depolarization to a maximum near the midpoint of the H+ conductance-voltage relationship, gH-V, and then decreased, supporting the idea that the noise is generated by H+ channel gating. Power spectral analysis indicated Lorentzian and 1/f components, both related to H+ currents. Unitary H+ current amplitude was estimated from stationary or quasi-stationary variance, sigmaH2. We analyze sigmaH2 data obtained at various voltages on a linearized plot that provides estimates of both unitary conductance and the number of channels in the patch, without requiring knowledge of open probability. The unitary conductance averaged 38 fS at pHi 6.5, and increased nearly fourfold to 140 fS at pHi 5.5, but was independent of pHo. In contrast, the macroscopic gH was only 1.8-fold larger at pHi 5.5 than at pHi 6.5. The maximum H+ channel open probability during large depolarizations was 0.75 at pHi 6.5 and 0.95 at pHi 5.5. Because the unitary conductance increases at lower pHi more than the macroscopic gH, the number of functional channels must decrease. Single H+ channel currents were too small to record directly at physiological pH, but at pHi < or = 5.5 near Vthreshold (the voltage at which gH turns on), single channel-like current events were observed with amplitudes 7-16 fA." @default.
• W2011424443 created "2016-06-24" @default.
• W2011424443 creator A5016708890 @default.
• W2011424443 creator A5037467900 @default.
• W2011424443 creator A5075078029 @default.
• W2011424443 creator A5079111353 @default.
• W2011424443 creator A5087877879 @default.
• W2011424443 date "2003-05-27" @default.
• W2011424443 modified "2023-10-16" @default.
• W2011424443 title "Properties of Single Voltage-gated Proton Channels in Human Eosinophils Estimated by Noise Analysis and by Direct Measurement" @default.
• W2011424443 cites W1967954078 @default.
• W2011424443 cites W1976102560 @default.
• W2011424443 cites W1996473697 @default.
• W2011424443 cites W1996786969 @default.
• W2011424443 cites W2002251481 @default.
• W2011424443 cites W2003173293 @default.
• W2011424443 cites W2006404213 @default.
• W2011424443 cites W2007326202 @default.
• W2011424443 cites W2026468876 @default.
• W2011424443 cites W2030441400 @default.
• W2011424443 cites W2033387624 @default.
• W2011424443 cites W2042447779 @default.
• W2011424443 cites W2045120197 @default.
• W2011424443 cites W2047597362 @default.
• W2011424443 cites W2059329234 @default.
• W2011424443 cites W2059542112 @default.
• W2011424443 cites W2060422389 @default.
• W2011424443 cites W2068032188 @default.
• W2011424443 cites W2068968931 @default.
• W2011424443 cites W2074083906 @default.
• W2011424443 cites W2097710660 @default.
• W2011424443 cites W2098996592 @default.
• W2011424443 cites W2099654960 @default.
• W2011424443 cites W2103566186 @default.
• W2011424443 cites W2115579471 @default.
• W2011424443 cites W2119786838 @default.
• W2011424443 cites W2131841308 @default.
• W2011424443 cites W2151665507 @default.
• W2011424443 cites W2161744065 @default.
• W2011424443 cites W2171548189 @default.
• W2011424443 cites W2187470775 @default.
• W2011424443 doi "https://doi.org/10.1085/jgp.200308813" @default.
• W2011424443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2217352" @default.
• W2011424443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12771195" @default.
• W2011424443 hasPublicationYear "2003" @default.
• W2011424443 type Work @default.
• W2011424443 sameAs 2011424443 @default.
• W2011424443 citedByCount "83" @default.
• W2011424443 countsByYear W20114244432012 @default.
• W2011424443 countsByYear W20114244432013 @default.
• W2011424443 countsByYear W20114244432014 @default.
• W2011424443 countsByYear W20114244432015 @default.
• W2011424443 countsByYear W20114244432016 @default.
• W2011424443 countsByYear W20114244432017 @default.
• W2011424443 countsByYear W20114244432018 @default.
• W2011424443 countsByYear W20114244432019 @default.
• W2011424443 countsByYear W20114244432021 @default.
• W2011424443 countsByYear W20114244432022 @default.
• W2011424443 countsByYear W20114244432023 @default.
• W2011424443 crossrefType "journal-article" @default.
• W2011424443 hasAuthorship W2011424443A5016708890 @default.
• W2011424443 hasAuthorship W2011424443A5037467900 @default.
• W2011424443 hasAuthorship W2011424443A5075078029 @default.
• W2011424443 hasAuthorship W2011424443A5079111353 @default.
• W2011424443 hasAuthorship W2011424443A5087877879 @default.
• W2011424443 hasBestOaLocation W20114244431 @default.
• W2011424443 hasConcept C113196181 @default.
• W2011424443 hasConcept C115961682 @default.
• W2011424443 hasConcept C121332964 @default.
• W2011424443 hasConcept C121932024 @default.
• W2011424443 hasConcept C12554922 @default.
• W2011424443 hasConcept C154945302 @default.
• W2011424443 hasConcept C181911157 @default.
• W2011424443 hasConcept C184779094 @default.
• W2011424443 hasConcept C185592680 @default.
• W2011424443 hasConcept C194544171 @default.
• W2011424443 hasConcept C26873012 @default.
• W2011424443 hasConcept C41008148 @default.
• W2011424443 hasConcept C4141045 @default.
• W2011424443 hasConcept C41999313 @default.
• W2011424443 hasConcept C43617362 @default.
• W2011424443 hasConcept C54516573 @default.
• W2011424443 hasConcept C55493867 @default.
• W2011424443 hasConcept C62520636 @default.
• W2011424443 hasConcept C86803240 @default.
• W2011424443 hasConcept C99498987 @default.
• W2011424443 hasConceptScore W2011424443C113196181 @default.
• W2011424443 hasConceptScore W2011424443C115961682 @default.
• W2011424443 hasConceptScore W2011424443C121332964 @default.
• W2011424443 hasConceptScore W2011424443C121932024 @default.
• W2011424443 hasConceptScore W2011424443C12554922 @default.
• W2011424443 hasConceptScore W2011424443C154945302 @default.
• W2011424443 hasConceptScore W2011424443C181911157 @default.
• W2011424443 hasConceptScore W2011424443C184779094 @default.
• W2011424443 hasConceptScore W2011424443C185592680 @default.
• W2011424443 hasConceptScore W2011424443C194544171 @default.
• W2011424443 hasConceptScore W2011424443C26873012 @default.
• W2011424443 hasConceptScore W2011424443C41008148 @default.

• next