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- W2032913694 abstract "Peroxisome proliferator-activated receptor gamma-coactivator-1alpha (PGC-1alpha) is a key coordinator of gene programs in metabolism and energy homeostasis in mammals. It is highly responsive to changes in the cellular environment and physiological status of mammals and regulated by post-translational modifications: acetylation, phosphorylation, and methylation. Here, we show that PGC-1alpha is covalently modified by small ubiquitin-like modifier (SUMO) 1 protein, an important regulator of signaling and transcription. Conserved lysine residue 183 located in the activation domain of PGC-1alpha was identified as the major site of SUMO conjugation. Interestingly, the same Lys residue is also a target for acetylation. Therefore, the E185A mutation disrupting the SUMOylation consensus sequence was utilized to show that SUMOylation plays a role in the regulation of PGC-1alpha function. Our results show that SUMOylation does not have an apparent effect on the subcellular localization or the stability of PGC-1alpha, but it attenuates the transcriptional activity of the coactivator, probably by enhancing the interaction of PGC-1alpha with corepressor RIP140. Mutation that abolished the SUMOylation augments the activity of PGC-1alpha also in the context of PPARgamma-dependent transcription. Thus, our findings showing that reversible SUMOylation can adjust the activity of PGC-1alpha add a novel layer to the regulation of the coactivator." @default.
- W2032913694 created "2016-06-24" @default.
- W2032913694 creator A5078266579 @default.
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- W2032913694 date "2009-09-01" @default.
- W2032913694 modified "2023-10-01" @default.
- W2032913694 title "SUMOylation Attenuates the Function of PGC-1α" @default.
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- W2032913694 doi "https://doi.org/10.1074/jbc.m109.038943" @default.
- W2032913694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2758017" @default.
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