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- W2151230405 abstract "Stimulation of receptors and subsequent signal transduction results in the activation of arachidonic acid (AA) release. Once AA is released from phospholipids or others esters, it may be metabolized via the cycloxygenase or the lipoxygenase pathways. How the cells drive AA to these pathways is not elucidated yet. It is reasonable to speculate that each pathway will have different sources of free AA triggered by different signal transduction pathways. Several reports have shown that AA and its lipoxygenase-catalyzed metabolites play essential roles in the regulation of steroidogenesis by influencing cholesterol transport from the outer to the inner mitochondrial membrane, the rate-limiting step in steroid hormone biosynthesis. Signals that stimulate steroidogenesis also cause the release of AA from phospholipids or other esters by mechanisms that are not fully understood. This review focuses on the enzymes of AA release that impact on steroidogenesis." @default.
- W2151230405 created "2016-06-24" @default.
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- W2151230405 date "2007-02-01" @default.
- W2151230405 modified "2023-10-17" @default.
- W2151230405 title "Enzymes involved in arachidonic acid release in adrenal and Leydig cells" @default.
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- W2151230405 doi "https://doi.org/10.1016/j.mce.2006.12.026" @default.
- W2151230405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17207922" @default.
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