FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2336531272> ?p ?o ?g. }

• W2336531272 endingPage "2071" @default.
• W2336531272 startingPage "2061" @default.
• W2336531272 abstract "Fischer, Thomas M., Robert S. Zucker, and Thomas J. Carew. Activity-dependent potentiation of synaptic transmission from L30 inhibitory interneurons of Aplysia depends on residual presynaptic Ca 2+ but not on postsynaptic Ca 2+ . J. Neurophysiol. 78: 2061–2071, 1997. Activity-induced short-term synaptic enhancement (STE) is a common property of neurons, one that can endow neural circuits with the capacity for rapid and flexible information processing. Evidence from a variety of systems indicates that the expression of STE depends largely on the action of residual Ca 2+ , which enters the presynaptic terminal during activity. We have shown previously that a Ca 2+ -dependent STE in the inhibitory synapse between interneurons L30 and L29 in the abdominal ganglion of Aplysia californica has a functional role in regulating the gain of the siphon withdrawal circuit through facilitated recurrent inhibition onto the L29s. In the present paper, we further explore the role of Ca 2+ in L30 STE by examining two basic issues: 1) What is the role of residual presynaptic Ca 2+ in the maintenance of L30 STE? We examine this question by first inducing STE in the L30s then rapidly buffering presynaptic free calcium through the use of the photoactivated Ca 2+ chelator diazo-4, which was preloaded into the L30 neurons. Three forms of STE in the L30s were examined: frequency facilitation (FF), augmentation (AUG), and posttetanic potentiation (PTP). In each case, the activation-induced enhancement of the L30 to L29 synapse was reduced to preactivation levels at the first test pulse following photolysis of diazo-4. 2) What is the role of postsynaptic Ca 2+ in the induction of L30 STE? We examine whether there is a postsynaptic requirement of elevated Ca 2+ for the induction of L30 STE by first injecting the calcium chelator bis-( o-aminophenoxy)- N,N,N′,N′-tetraacetic acid (BAPTA) into the postsynaptic cell L29 (at levels sufficient to block transmitter release from the L29s), to prevent any increase in postsynaptic intracellular Ca 2+ that may occur during L30 (presynaptic) activation. We found that BAPTA injection did not effect either the induction or the time course of FF, AUG, or PTP in the L30s. Taken collectively, our data indicate that all forms of STE in the L30s depend on presynaptic free cytosolic Ca 2+ for their maintenance but do not require the elevation of postsynaptic Ca 2+ for their induction." @default.
• W2336531272 created "2016-06-24" @default.
• W2336531272 creator A5038548984 @default.
• W2336531272 creator A5046481259 @default.
• W2336531272 creator A5087204052 @default.
• W2336531272 date "1997-10-01" @default.
• W2336531272 modified "2023-09-26" @default.
• W2336531272 title "Activity-Dependent Potentiation of Synaptic Transmission From L30 Inhibitory Interneurons of Aplysia Depends on Residual Presynaptic Ca2+ But Not on Postsynaptic Ca2+" @default.
• W2336531272 cites W1495670189 @default.
• W2336531272 cites W1520756199 @default.
• W2336531272 cites W1540799962 @default.
• W2336531272 cites W1550564753 @default.
• W2336531272 cites W1647105274 @default.
• W2336531272 cites W1671421450 @default.
• W2336531272 cites W1704992928 @default.
• W2336531272 cites W1871340357 @default.
• W2336531272 cites W1904014509 @default.
• W2336531272 cites W1974217719 @default.
• W2336531272 cites W1977871443 @default.
• W2336531272 cites W1988007470 @default.
• W2336531272 cites W1995484013 @default.
• W2336531272 cites W1999772445 @default.
• W2336531272 cites W2010463725 @default.
• W2336531272 cites W2012539867 @default.
• W2336531272 cites W2023013885 @default.
• W2336531272 cites W2029437307 @default.
• W2336531272 cites W2034780161 @default.
• W2336531272 cites W2036050784 @default.
• W2336531272 cites W2049511526 @default.
• W2336531272 cites W2049541916 @default.
• W2336531272 cites W2059075177 @default.
• W2336531272 cites W2062965165 @default.
• W2336531272 cites W2065027139 @default.
• W2336531272 cites W2069258252 @default.
• W2336531272 cites W2070235828 @default.
• W2336531272 cites W2079812974 @default.
• W2336531272 cites W2088479551 @default.
• W2336531272 cites W2088634481 @default.
• W2336531272 cites W2098944279 @default.
• W2336531272 cites W2117088111 @default.
• W2336531272 cites W2131394376 @default.
• W2336531272 cites W2144497288 @default.
• W2336531272 cites W2147309752 @default.
• W2336531272 cites W2169873791 @default.
• W2336531272 cites W2190543657 @default.
• W2336531272 cites W2404954459 @default.
• W2336531272 cites W2443294675 @default.
• W2336531272 cites W3021526609 @default.
• W2336531272 doi "https://doi.org/10.1152/jn.1997.78.4.2061" @default.
• W2336531272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9325373" @default.
• W2336531272 hasPublicationYear "1997" @default.
• W2336531272 type Work @default.
• W2336531272 sameAs 2336531272 @default.
• W2336531272 citedByCount "12" @default.
• W2336531272 countsByYear W23365312722013 @default.
• W2336531272 countsByYear W23365312722023 @default.
• W2336531272 crossrefType "journal-article" @default.
• W2336531272 hasAuthorship W2336531272A5038548984 @default.
• W2336531272 hasAuthorship W2336531272A5046481259 @default.
• W2336531272 hasAuthorship W2336531272A5087204052 @default.
• W2336531272 hasBestOaLocation W23365312721 @default.
• W2336531272 hasConcept C112592302 @default.
• W2336531272 hasConcept C118232355 @default.
• W2336531272 hasConcept C12554922 @default.
• W2336531272 hasConcept C127445978 @default.
• W2336531272 hasConcept C169760540 @default.
• W2336531272 hasConcept C170493617 @default.
• W2336531272 hasConcept C17077164 @default.
• W2336531272 hasConcept C185592680 @default.
• W2336531272 hasConcept C197341189 @default.
• W2336531272 hasConcept C200170125 @default.
• W2336531272 hasConcept C25274449 @default.
• W2336531272 hasConcept C2778178740 @default.
• W2336531272 hasConcept C2910581834 @default.
• W2336531272 hasConcept C29561615 @default.
• W2336531272 hasConcept C55493867 @default.
• W2336531272 hasConcept C86803240 @default.
• W2336531272 hasConcept C98229152 @default.
• W2336531272 hasConceptScore W2336531272C112592302 @default.
• W2336531272 hasConceptScore W2336531272C118232355 @default.
• W2336531272 hasConceptScore W2336531272C12554922 @default.
• W2336531272 hasConceptScore W2336531272C127445978 @default.
• W2336531272 hasConceptScore W2336531272C169760540 @default.
• W2336531272 hasConceptScore W2336531272C170493617 @default.
• W2336531272 hasConceptScore W2336531272C17077164 @default.
• W2336531272 hasConceptScore W2336531272C185592680 @default.
• W2336531272 hasConceptScore W2336531272C197341189 @default.
• W2336531272 hasConceptScore W2336531272C200170125 @default.
• W2336531272 hasConceptScore W2336531272C25274449 @default.
• W2336531272 hasConceptScore W2336531272C2778178740 @default.
• W2336531272 hasConceptScore W2336531272C2910581834 @default.
• W2336531272 hasConceptScore W2336531272C29561615 @default.
• W2336531272 hasConceptScore W2336531272C55493867 @default.
• W2336531272 hasConceptScore W2336531272C86803240 @default.
• W2336531272 hasConceptScore W2336531272C98229152 @default.
• W2336531272 hasIssue "4" @default.
• W2336531272 hasLocation W23365312721 @default.
• W2336531272 hasLocation W23365312722 @default.

• next