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- W4244055184 abstract "The key to optimal treatment is early recognition of acute liver failure, determining the aetiology, estimating the severity and, if appropriate, transfer to a facility capable of liver transplantation. Knowing the aetiology can help determine when transplant evaluation should be performed; paracetamol patients do relatively well, while Wilson disease and drug-induced liver injury patients are unlikely to survive without transplant. Patients can be divided into hyperacute (paracetamol, primarily) and subacute (drug-induced, autoimmune, hepatitis B). Treatment has focused on the management of complications except for a few aetiology-specific therapies. However, a recent double-blind placebo controlled trial of intravenous N-acetylcysteine (NAC) demonstrated improved transplant-free survival in non-paracetamol acute liver failure patients with early stage encephalopathy, perhaps offering a common therapy for fulminant hepatic failure. High-volume plasma exchange has been subjected to a controlled trial with limited positive results." @default.
- W4244055184 created "2022-05-12" @default.
- W4244055184 creator A5007927701 @default.
- W4244055184 creator A5070467866 @default.
- W4244055184 date "2018-06-15" @default.
- W4244055184 modified "2023-10-14" @default.
- W4244055184 title "Acute Liver Failure" @default.
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- W4244055184 doi "https://doi.org/10.1002/9781119237662.ch5" @default.
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