Matches in SemOpenAlex for { <https://semopenalex.org/work/W4322154885> ?p ?o ?g. }
- W4322154885 abstract "Abstract Salient cues, such as the rising sun or the availability of food, play a crucial role in entraining biological clocks, allowing for effective behavioral adaptation and ultimately, survival. While the light-dependent entrainment of the central circadian pacemaker (suprachiasmatic nucleus, SCN) is relatively well defined, the molecular and neural mechanisms underlying entrainment associated with food availability remains elusive. Using single nucleus RNA sequencing during scheduled feeding (SF), we identified a leptin receptor (LepR) expressing neuron population in the dorsomedial hypothalamus (DMH) that upregulates circadian entrainment genes and exhibits rhythmic calcium activity prior to an anticipated meal. We found that disrupting DMH LepR neuron activity had a profound impact on both molecular and behavioral food entrainment. Specifically, silencing DMH LepR neurons, mis-timed exogenous leptin administration, or mis-timed chemogenetic stimulation of these neurons all interfered with the development of food entrainment. In a state of energy abundance, repetitive activation of DMH LepR neurons led to the partitioning of a secondary bout of circadian locomotor activity that was in phase with the stimulation and dependent on an intact SCN. Lastly, we discovered that a subpopulation of DMH LepR neurons project to the SCN with the capacity to influence the phase of the circadian clock. This leptin regulated circuit serves as a point of integration between the metabolic and circadian systems, facilitating the anticipation of meal times." @default.
- W4322154885 created "2023-02-27" @default.
- W4322154885 creator A5001382395 @default.
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- W4322154885 date "2023-02-26" @default.
- W4322154885 modified "2023-09-23" @default.
- W4322154885 title "A leptin-responsive hypothalamic circuit inputs to the circadian feeding network" @default.
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