FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W100014986> ?p ?o ?g. }

• W100014986 endingPage "353" @default.
• W100014986 startingPage "347" @default.
• W100014986 abstract "In the presence of 5 microM-DL-propranolol and in HCO3(-)-containing buffers, 1 microM-adrenaline acutely stimulated protein synthesis by about 25% in the anterogradely perfused rat heart. This stimulation was opposed by low (1-10 nM) concentrations of prazosin, but not by similar concentrations of yohimbine, suggesting involvement of the alpha 1-adrenoceptor. Under the same conditions, adrenaline raised intracellular pH (pHi) by about 0.1 unit. The increase in pHi induced by adrenaline was prevented by 5 nM-prazosin, but not by 5 nM-yohimbine, again suggesting involvement of the alpha 1-adrenoceptor. Since an increase in pHi stimulates protein synthesis in the heart [Sugden & Fuller (1991) Biochem. J. 273, 339-346], the increase in pHi induced by adrenaline may be involved in its stimulation of protein synthesis. Adrenaline also increased phosphocreatine concentrations. As discussed, the increase in pHi induced by adrenaline may be responsible for this effect. Using second-order polynomial regression analysis, we showed that rates of protein synthesis were significantly correlated (P less than 0.0001) with phosphocreatine concentrations. We discuss two possible reasons for this correlation: (i) increases in pHi stimulate protein synthesis and separately raise phosphocreatine concentrations, or (ii) the increase in protein synthesis rates is a consequence of the raised phosphocreatine concentrations induced by the increase in pHi. Rates of protein synthesis were not significantly correlated with ATP/ADP concentration ratios, nor with any of the following: ATP, ADP, AMP or total adenine nucleotide concentrations. In freshly isolated adult rat cardiomyocytes, the protein kinase inhibitor staurosporine (1 microM) prevented stimulation of protein synthesis by 0.3 microM-adrenaline (and by 1 microM-phorbol 12-myristate 13-acetate or 1 m-unit of insulin/ml). The results are discussed within a mechanistic framework initiated by stimulation of the hydrolysis of membrane phospholipids by alpha 1-adrenergic agonists." @default.
• W100014986 created "2016-06-24" @default.
• W100014986 creator A5023948240 @default.
• W100014986 creator A5034536995 @default.
• W100014986 creator A5054676735 @default.
• W100014986 creator A5062259292 @default.
• W100014986 date "1991-01-15" @default.
• W100014986 modified "2023-10-14" @default.
• W100014986 title "Acute α1-adrenergic stimulation of cardiac protein synthesis may involve increased intracellular pH and protein kinase activity" @default.
• W100014986 cites W12195305 @default.
• W100014986 cites W126125509 @default.
• W100014986 cites W1481795044 @default.
• W100014986 cites W1497671643 @default.
• W100014986 cites W1508152421 @default.
• W100014986 cites W1552006396 @default.
• W100014986 cites W178963243 @default.
• W100014986 cites W1798074647 @default.
• W100014986 cites W1840325563 @default.
• W100014986 cites W1969252273 @default.
• W100014986 cites W1978131706 @default.
• W100014986 cites W1988183722 @default.
• W100014986 cites W1993123204 @default.
• W100014986 cites W1998413052 @default.
• W100014986 cites W2011987388 @default.
• W100014986 cites W2023045129 @default.
• W100014986 cites W2048832222 @default.
• W100014986 cites W2049728577 @default.
• W100014986 cites W2067887167 @default.
• W100014986 cites W2072229502 @default.
• W100014986 cites W2078126711 @default.
• W100014986 cites W2085812290 @default.
• W100014986 cites W2090464224 @default.
• W100014986 cites W2091251504 @default.
• W100014986 cites W2091544447 @default.
• W100014986 cites W2098572496 @default.
• W100014986 cites W2107862140 @default.
• W100014986 cites W2121795796 @default.
• W100014986 cites W2124967483 @default.
• W100014986 cites W2126418187 @default.
• W100014986 cites W2136189765 @default.
• W100014986 cites W2166391600 @default.
• W100014986 cites W2171160325 @default.
• W100014986 cites W2177574648 @default.
• W100014986 cites W2221321345 @default.
• W100014986 cites W2233118515 @default.
• W100014986 cites W2284288402 @default.
• W100014986 cites W2337521362 @default.
• W100014986 cites W2398863814 @default.
• W100014986 cites W2405902252 @default.
• W100014986 cites W2410333027 @default.
• W100014986 cites W2423474938 @default.
• W100014986 cites W47709512 @default.
• W100014986 cites W62801586 @default.
• W100014986 doi "https://doi.org/10.1042/bj2730347" @default.
• W100014986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1149852" @default.
• W100014986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1671330" @default.
• W100014986 hasPublicationYear "1991" @default.
• W100014986 type Work @default.
• W100014986 sameAs 100014986 @default.
• W100014986 citedByCount "23" @default.
• W100014986 countsByYear W1000149862013 @default.
• W100014986 countsByYear W1000149862022 @default.
• W100014986 crossrefType "journal-article" @default.
• W100014986 hasAuthorship W100014986A5023948240 @default.
• W100014986 hasAuthorship W100014986A5034536995 @default.
• W100014986 hasAuthorship W100014986A5054676735 @default.
• W100014986 hasAuthorship W100014986A5062259292 @default.
• W100014986 hasBestOaLocation W1000149862 @default.
• W100014986 hasConcept C126322002 @default.
• W100014986 hasConcept C134018914 @default.
• W100014986 hasConcept C134897140 @default.
• W100014986 hasConcept C170493617 @default.
• W100014986 hasConcept C184235292 @default.
• W100014986 hasConcept C185592680 @default.
• W100014986 hasConcept C195794163 @default.
• W100014986 hasConcept C24998067 @default.
• W100014986 hasConcept C2775859304 @default.
• W100014986 hasConcept C2776885963 @default.
• W100014986 hasConcept C2777676773 @default.
• W100014986 hasConcept C2778151854 @default.
• W100014986 hasConcept C2778626300 @default.
• W100014986 hasConcept C2779084600 @default.
• W100014986 hasConcept C2780648677 @default.
• W100014986 hasConcept C2986317502 @default.
• W100014986 hasConcept C3675279 @default.
• W100014986 hasConcept C55493867 @default.
• W100014986 hasConcept C71924100 @default.
• W100014986 hasConcept C79879829 @default.
• W100014986 hasConcept C86803240 @default.
• W100014986 hasConcept C97029542 @default.
• W100014986 hasConceptScore W100014986C126322002 @default.
• W100014986 hasConceptScore W100014986C134018914 @default.
• W100014986 hasConceptScore W100014986C134897140 @default.
• W100014986 hasConceptScore W100014986C170493617 @default.
• W100014986 hasConceptScore W100014986C184235292 @default.
• W100014986 hasConceptScore W100014986C185592680 @default.
• W100014986 hasConceptScore W100014986C195794163 @default.
• W100014986 hasConceptScore W100014986C24998067 @default.

• next