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- W1032457906 abstract "This chapter presents the advances made in molecular biological efforts on transmitters that coexist, and it also considers some of the opportunities and puzzles that lie ahead. Two series of developments over the past half decade that have made their impressive effects on the emerging list of transmitters are recognized. Both derive from the recognition of common chemical principles but use different ways to exploit the general feature. Mutt and colleagues looked at the frequent occurrence of C-terminally amidated peptides that functioned as messengers. By identifying other important molecules with this common structure, they found new peptide members of the glucagon–VIP family and the pancreatic polypeptide family. The second new approach is based on the central dogma of molecular biology—all peptides are synthesized under the direction of a specific messenger RNA (mRNA) encoded by the gene for that peptide. With the emergence of recombinant DNA technologies, restriction endonucleases, and nucleotide sequencing, a new opportunity for molecular discovery became available. Nakanishi et al. were the first to determine the precise sequence of the pro-hormone for opiocortin and discover that it contains an unanticipated third biologically relevant peptide, deduced solely from the mRNA sequence on the basis of its structural analogy to alpha and beta melanocyte-stimulating hormone (MSH)." @default.
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- W1032457906 date "1986-01-01" @default.
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- W1032457906 title "Chapter 10 Genetic background for multiple messengers" @default.
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- W1032457906 doi "https://doi.org/10.1016/s0079-6123(08)60236-8" @default.
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