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- W105847759 abstract "DNA has held the center stage as a target for antineoplastic drugs essentially since the beginning of cancer chemotherapy. The DNA as target concept has been productive, of course, because it has led to the development of a spectrum of drugs which are useful for treating human cancer. Moreover, many of these drugs have been thought to act at the level of DNA, either by binding to the nucleic acid directly or by interference with the enzymes participating in its biosynthesis. The insistence on DNA as the receptor for anticancer drug action has also served, at least to some extent, to distract attention from other potential targets and mechanisms. However, during the last decade numerous laboratories have contributed to the idea that the cell surface or plasma membrane may represent an attractive target both for new classes of drugs and as an alternative explanation for the action of certain existing agents. The cell surface offers several advantages as the receptor for antineoplastic drug action: (a) the outer surface of a cell is the first structure encountered by a drug and thus represents the first level at which specificity could operate. In this sense the plasma membrane acts as a screen or filter to regulate further access of the cell to agents with which it comes in contact; (b) the cell surface is intimately involved in the regulation of a host of biological functions." @default.
- W105847759 created "2016-06-24" @default.
- W105847759 creator A5013128561 @default.
- W105847759 creator A5069307194 @default.
- W105847759 date "1985-01-01" @default.
- W105847759 modified "2023-10-18" @default.
- W105847759 title "Cell Surface Membranes as a Chemotherapeutic Target" @default.
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