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- W111546727 abstract "479 Objectives To compare the diagnostic accuracy of Ga68-DOTATATE PET scan with CT scan for detection of bone metastases in paediatric neuroendocrine tumours. Methods Twenty five patients (15 males 10 females; age range 1-19 years; mean age 7.8 years) with histologically confirmed neuroendocrine tumours (16 neuroblastomas; 5 phaeochromocytomas; 2 pancreatic NETs; 1 paraganglioma; 1 ganglioneuroma) referred to our department were prospectively analysed. All patients underwent Ga68-DOTATATE PET scan and CT scan at the time of diagnosis for primary staging. Imaging results were analysed on a per-patient and on a per-lesion basis. Conventional imaging, clinical follow up and repeat imaging (wherever available) served as the reference standard. All statistical tests were done using SPSS software 16.0. The statistical significance of differences in sensitivity and specificity between 68Ga-DOTATATE PET scan and CT scan were calculated using the Fischer exact test, and differences on a per-patient and per-lesion basis were evaluated using the McNemar test. Results Thirteen of twenty five patients had no evidence of bone metastases on any imaging modality or on clinical follow up while the rest of twelve patients were true-positive for bone metastases on 68Ga-DOTATATE PET resulting in a sensitivity and specificity of 100% (p Conclusions 68Ga-DOTATATE PET is more useful than conventional CT scan for detection of bone metastases for primary staging in paediatric neuro endocrine tumours." @default.
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- W111546727 date "2013-05-01" @default.
- W111546727 modified "2023-09-26" @default.
- W111546727 title "Comparison of Ga68-DOTATATE PET scan with CT scan for detection of bone metastases in paediatric neuroendocrine tumours" @default.
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