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- W1479306722 endingPage "268" @default.
- W1479306722 startingPage "215" @default.
- W1479306722 abstract "The variations of human hemoglobin provide a valuable tool for the investigation of protein homogeneity and heterogeneity, and of the genetic control of protein synthesis. A number of techniques for the detection of heterogeneity in hemoglobin have been evaluated, and some have been shown to provide ambiguous results. Their basic deficiency is either that they compare two observations taken under different conditions, or that they induce heterogeneity not present in the original sample. The heterogeneity of human hemoglobin results from the existence of adult hemoglobin, fetal hemoglobin, and a minor component, hemoglobin A2. The proportions in which two hemoglobins occur in an individual can be related to relative net rates of synthesis. The factors that govern the relative rates of synthesis of adult and fetal hemoglobin during transition from fetal to adult metabolism are not known. The term “thalassemia” is applied to conditions associated with marked inhibition of net rate of synthesis of adult hemoglobin without detectable alteration of physical properties. Total or partial inhibition may occur, and it is likely that mutations at more than one locus are grouped under the general category of thalassemia. The postulate of rate-controlling mutants at the Hb locus accounts for the existence of phenotypically normal red cells in individuals who carry a thalassemia allele." @default.
- W1479306722 created "2016-06-24" @default.
- W1479306722 creator A5060330432 @default.
- W1479306722 date "1957-01-01" @default.
- W1479306722 modified "2023-09-26" @default.
- W1479306722 title "The Human Hemoglobins: Their Properties and Genetic Control" @default.
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