FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517658545> ?p ?o ?g. }

• W1517658545 endingPage "1752" @default.
• W1517658545 startingPage "1746" @default.
• W1517658545 abstract "The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this further using stable transfection of the mdm2 gene into 4 well-characterised human paediatric rhabdomyosarcoma cell lines. Transfection with the mdm2 gene resulted in increased levels of the MDM2 protein in all the cell lines. In 2 of the lines, SCMC and RD, the mdm2 gene caused between 2-fold and 61-fold increase in resistance to vincristine, etoposide and doxorubicin but not to cisplatin. In these lines there was an increase in expression of the mdr-1 gene which encodes P-glycoprotein, but not the mrp1 gene which encodes the multidrug resistance protein (MRP). The resistance was reversible using the MDR modulator PSC833, confirming the presence of P-glycoprotein. We conclude that MDM2 overexpression may be a mechanism by which multidrug resistance is regulated in some rhabdomyosarcomas." @default.
• W1517658545 created "2016-06-24" @default.
• W1517658545 creator A5017524713 @default.
• W1517658545 creator A5035410237 @default.
• W1517658545 creator A5041062763 @default.
• W1517658545 creator A5054947910 @default.
• W1517658545 creator A5062637825 @default.
• W1517658545 creator A5081938356 @default.
• W1517658545 date "2001-11-27" @default.
• W1517658545 modified "2023-10-10" @default.
• W1517658545 title "High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance" @default.
• W1517658545 cites W1595867557 @default.
• W1517658545 cites W165238907 @default.
• W1517658545 cites W1974291651 @default.
• W1517658545 cites W1978222385 @default.
• W1517658545 cites W1984440269 @default.
• W1517658545 cites W1990952117 @default.
• W1517658545 cites W1997445678 @default.
• W1517658545 cites W2030757642 @default.
• W1517658545 cites W2040146891 @default.
• W1517658545 cites W2050917153 @default.
• W1517658545 cites W2052507438 @default.
• W1517658545 cites W2059062271 @default.
• W1517658545 cites W2068336659 @default.
• W1517658545 cites W2076149108 @default.
• W1517658545 cites W2080736726 @default.
• W1517658545 cites W2090422621 @default.
• W1517658545 cites W2104733808 @default.
• W1517658545 cites W2114918609 @default.
• W1517658545 cites W2171983186 @default.
• W1517658545 cites W2248842252 @default.
• W1517658545 cites W2319897304 @default.
• W1517658545 doi "https://doi.org/10.1054/bjoc.2001.2145" @default.
• W1517658545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363993" @default.
• W1517658545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11742497" @default.
• W1517658545 hasPublicationYear "2001" @default.
• W1517658545 type Work @default.
• W1517658545 sameAs 1517658545 @default.
• W1517658545 citedByCount "26" @default.
• W1517658545 countsByYear W15176585452012 @default.
• W1517658545 countsByYear W15176585452013 @default.
• W1517658545 countsByYear W15176585452015 @default.
• W1517658545 countsByYear W15176585452016 @default.
• W1517658545 countsByYear W15176585452017 @default.
• W1517658545 countsByYear W15176585452019 @default.
• W1517658545 countsByYear W15176585452021 @default.
• W1517658545 crossrefType "journal-article" @default.
• W1517658545 hasAuthorship W1517658545A5017524713 @default.
• W1517658545 hasAuthorship W1517658545A5035410237 @default.
• W1517658545 hasAuthorship W1517658545A5041062763 @default.
• W1517658545 hasAuthorship W1517658545A5054947910 @default.
• W1517658545 hasAuthorship W1517658545A5062637825 @default.
• W1517658545 hasAuthorship W1517658545A5081938356 @default.
• W1517658545 hasBestOaLocation W15176585451 @default.
• W1517658545 hasConcept C104317684 @default.
• W1517658545 hasConcept C114851261 @default.
• W1517658545 hasConcept C133936738 @default.
• W1517658545 hasConcept C142724271 @default.
• W1517658545 hasConcept C153911025 @default.
• W1517658545 hasConcept C2776192174 @default.
• W1517658545 hasConcept C2776694085 @default.
• W1517658545 hasConcept C2776755627 @default.
• W1517658545 hasConcept C2778119113 @default.
• W1517658545 hasConcept C2778256501 @default.
• W1517658545 hasConcept C2778707650 @default.
• W1517658545 hasConcept C2779429289 @default.
• W1517658545 hasConcept C2780844630 @default.
• W1517658545 hasConcept C2781018059 @default.
• W1517658545 hasConcept C2781303535 @default.
• W1517658545 hasConcept C29537977 @default.
• W1517658545 hasConcept C502942594 @default.
• W1517658545 hasConcept C54009773 @default.
• W1517658545 hasConcept C54355233 @default.
• W1517658545 hasConcept C71924100 @default.
• W1517658545 hasConcept C81885089 @default.
• W1517658545 hasConcept C86803240 @default.
• W1517658545 hasConceptScore W1517658545C104317684 @default.
• W1517658545 hasConceptScore W1517658545C114851261 @default.
• W1517658545 hasConceptScore W1517658545C133936738 @default.
• W1517658545 hasConceptScore W1517658545C142724271 @default.
• W1517658545 hasConceptScore W1517658545C153911025 @default.
• W1517658545 hasConceptScore W1517658545C2776192174 @default.
• W1517658545 hasConceptScore W1517658545C2776694085 @default.
• W1517658545 hasConceptScore W1517658545C2776755627 @default.
• W1517658545 hasConceptScore W1517658545C2778119113 @default.
• W1517658545 hasConceptScore W1517658545C2778256501 @default.
• W1517658545 hasConceptScore W1517658545C2778707650 @default.
• W1517658545 hasConceptScore W1517658545C2779429289 @default.
• W1517658545 hasConceptScore W1517658545C2780844630 @default.
• W1517658545 hasConceptScore W1517658545C2781018059 @default.
• W1517658545 hasConceptScore W1517658545C2781303535 @default.
• W1517658545 hasConceptScore W1517658545C29537977 @default.
• W1517658545 hasConceptScore W1517658545C502942594 @default.
• W1517658545 hasConceptScore W1517658545C54009773 @default.
• W1517658545 hasConceptScore W1517658545C54355233 @default.
• W1517658545 hasConceptScore W1517658545C71924100 @default.
• W1517658545 hasConceptScore W1517658545C81885089 @default.
• W1517658545 hasConceptScore W1517658545C86803240 @default.

• next