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- W15241012 abstract "Airway mucus is certainly abnormal in asthma. There have been a number of important advances in the investigation of airway mucus in asthma. First, at least in one patient dying of asthma, some mucin species in the mucous plug are intrinsically abnormal, with their biophysical profile consistent with high viscosity. Second, goblet cells retain continuity with their secreted mucin in asthmatic airways but not in normal or chronic bronchitic airways. Third, macrophage/ monocyte-derived mucous secretagogues (MMS)-68, although not specific for asthma, may be a marker for severe hypersecretory disease and may merit therapeutic targeting. Fourth, improved molecular biological techniques have started to unravel the complexities of mucin genes; this has enabled tissue localization and has shown that certain cytokines can upregulate mucin gene expression. Thus, tools are becoming available to determine differences in gene expression between normal states and different diseases and to study mucin gene regulation. Several advances in the pharmaceutical industry have allowed the development of a wide variety of selective molecules—including tachykinin antagonists, leukotriene antagonists, and K+ channel activators—which open the options for the treatment of asthma and airway mucous hypersecretion." @default.
- W15241012 created "2016-06-24" @default.
- W15241012 creator A5004468136 @default.
- W15241012 creator A5005714301 @default.
- W15241012 creator A5028401093 @default.
- W15241012 date "1998-01-01" @default.
- W15241012 modified "2023-10-17" @default.
- W15241012 title "Pathophysiology of Airway Mucus Secretion in Asthma" @default.
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