FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554767868> ?p ?o ?g. }

• W1554767868 abstract "Mononuclear phagocytes like monocytes/macrophages engulf microbes and mediate intracellular killing through different mechanisms such as production of anti-microbial peptides, reactive oxygen/nitrogen intermediates and autophagy induction. However, intracellular pathogens like M. tuberculosis evades from macrophage defense mechanisms by various strategies to adapt the intracellular environment of macrophages and creating a major host cell niche for its growth and survival. 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] is the active form of vitamin D, which is shown to be involved in immuno-modulation in various immune cells including macrophages. Genomic actions of 1,25(OH) 2 D 3 exert through vitamin D receptor, which is expressed constitutively in macrophages. Various studies revealed that 1,25(OH) 2 D 3 enhances the macrophage phacocytosis by upregulating the surface receptors including CD14 and mannose receptor. Moreover, 1,25(OH) 2 D 3 enhances the antimicrobial effects of macrophages by upregulating the expression of antimicrobial peptides such as cathelicidin and defensin, which inhibit the intracellular growth of M. tuberculosis . 1,25(OH) 2 D 3 mediated cathelicidin expression upregulates the autophagy genes and enhance the fusion of phagosome containing M. tuberculosis with lysosome. Apart from antimicrobial effects, 1,25(OH) 2 D 3 also modulates the antigen presentation and secretion of chemokines, cytokines and other factors of macrophages. In conclusion, it has been suggested that 1,25(OH) 2 D 3 enhances macrophage innate immune functions by upregulating the antimicrobial efficiency, which could be beneficial to the host during active tuberculosis disease. This suggests that vitamin D supplementation may be useful as an adjunct during anti-TB treatment in tuberculosis." @default.
• W1554767868 created "2016-06-24" @default.
• W1554767868 creator A5039492176 @default.
• W1554767868 creator A5047318755 @default.
• W1554767868 creator A5077349386 @default.
• W1554767868 date "2015-05-02" @default.
• W1554767868 modified "2023-09-27" @default.
• W1554767868 title "Vitamin D and Macrophage Functions in Tuberculosis" @default.
• W1554767868 cites W1528645406 @default.
• W1554767868 cites W1588120420 @default.
• W1554767868 cites W1604836617 @default.
• W1554767868 cites W1817088045 @default.
• W1554767868 cites W1818948961 @default.
• W1554767868 cites W1880207624 @default.
• W1554767868 cites W1881370365 @default.
• W1554767868 cites W1898771364 @default.
• W1554767868 cites W1903933791 @default.
• W1554767868 cites W1927671826 @default.
• W1554767868 cites W1955379330 @default.
• W1554767868 cites W1971756895 @default.
• W1554767868 cites W1972181361 @default.
• W1554767868 cites W1973875208 @default.
• W1554767868 cites W1975516225 @default.
• W1554767868 cites W1975795847 @default.
• W1554767868 cites W1978993402 @default.
• W1554767868 cites W198103589 @default.
• W1554767868 cites W1983129403 @default.
• W1554767868 cites W1993967111 @default.
• W1554767868 cites W1994238246 @default.
• W1554767868 cites W1994698540 @default.
• W1554767868 cites W2000498962 @default.
• W1554767868 cites W2002996942 @default.
• W1554767868 cites W2005427598 @default.
• W1554767868 cites W2011807378 @default.
• W1554767868 cites W2012451546 @default.
• W1554767868 cites W2014262351 @default.
• W1554767868 cites W2016293419 @default.
• W1554767868 cites W2017641895 @default.
• W1554767868 cites W2019978786 @default.
• W1554767868 cites W2023772557 @default.
• W1554767868 cites W2034346287 @default.
• W1554767868 cites W2038689279 @default.
• W1554767868 cites W2041999173 @default.
• W1554767868 cites W2043045955 @default.
• W1554767868 cites W2044645610 @default.
• W1554767868 cites W2045480275 @default.
• W1554767868 cites W2051151603 @default.
• W1554767868 cites W2052426418 @default.
• W1554767868 cites W2052505493 @default.
• W1554767868 cites W2065321690 @default.
• W1554767868 cites W2067566672 @default.
• W1554767868 cites W2068650409 @default.
• W1554767868 cites W2070744750 @default.
• W1554767868 cites W2076649068 @default.
• W1554767868 cites W2079357214 @default.
• W1554767868 cites W2081199994 @default.
• W1554767868 cites W2082476464 @default.
• W1554767868 cites W2090941537 @default.
• W1554767868 cites W2091360431 @default.
• W1554767868 cites W2091442643 @default.
• W1554767868 cites W2095351093 @default.
• W1554767868 cites W2096504220 @default.
• W1554767868 cites W2097416981 @default.
• W1554767868 cites W2100266303 @default.
• W1554767868 cites W2101417884 @default.
• W1554767868 cites W2101781154 @default.
• W1554767868 cites W2103263770 @default.
• W1554767868 cites W2105622887 @default.
• W1554767868 cites W2106449126 @default.
• W1554767868 cites W2107072141 @default.
• W1554767868 cites W2110540179 @default.
• W1554767868 cites W2112523199 @default.
• W1554767868 cites W2116558722 @default.
• W1554767868 cites W2116654815 @default.
• W1554767868 cites W2120095412 @default.
• W1554767868 cites W2120234524 @default.
• W1554767868 cites W2120697418 @default.
• W1554767868 cites W2121256372 @default.
• W1554767868 cites W2124070987 @default.
• W1554767868 cites W2124580054 @default.
• W1554767868 cites W2128627731 @default.
• W1554767868 cites W2135995517 @default.
• W1554767868 cites W2137850244 @default.
• W1554767868 cites W2138258120 @default.
• W1554767868 cites W2143162403 @default.
• W1554767868 cites W2147098153 @default.
• W1554767868 cites W2147251439 @default.
• W1554767868 cites W2148594309 @default.
• W1554767868 cites W2151191790 @default.
• W1554767868 cites W2151925533 @default.
• W1554767868 cites W2155465613 @default.
• W1554767868 cites W2157243060 @default.
• W1554767868 cites W2160040629 @default.
• W1554767868 cites W2161519087 @default.
• W1554767868 cites W2162666820 @default.
• W1554767868 cites W2164309428 @default.
• W1554767868 cites W326173654 @default.
• W1554767868 cites W382757940 @default.
• W1554767868 cites W93578376 @default.
• W1554767868 doi "https://doi.org/10.14800/macrophage.756" @default.

• next