FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571991353> ?p ?o ?g. }

• W1571991353 endingPage "5956" @default.
• W1571991353 startingPage "5948" @default.
• W1571991353 abstract "Abstract Abs or their recombinant fragments against surface receptors of the Ig superfamily can induce or block the receptors’ native function depending on whether they induce or prevent the assembly of signalosomes on their cytoplasmic tails. In this study, we introduce a novel paradigm based on the observation that a bispecific tandem single-chain variable region fragment ligand of CTLA-4 by itself converts this inhibitory receptor into an activating receptor for primary human T lymphocytes. This reversal of function results from increased recruitment of the serine/threonine phosphatase 2A to the cytoplasmic tail of CTLA-4, consistent with a role of this phosphatase in the regulation of CTLA-4 function, and assembly of a distinct signalosome that activates an lck-dependent signaling cascade and induces IL-2 production. Our data demonstrate that the cytoplasmic domain of CTLA-4 has an inherent plasticity for signaling that can be exploited therapeutically with recombinant ligands for this receptor." @default.
• W1571991353 created "2016-06-24" @default.
• W1571991353 creator A5000653097 @default.
• W1571991353 creator A5011133492 @default.
• W1571991353 creator A5019714017 @default.
• W1571991353 creator A5043749098 @default.
• W1571991353 creator A5056636501 @default.
• W1571991353 creator A5056785682 @default.
• W1571991353 creator A5064126401 @default.
• W1571991353 creator A5078013894 @default.
• W1571991353 date "2004-05-15" @default.
• W1571991353 modified "2023-10-16" @default.
• W1571991353 title "Conversion of CTLA-4 from Inhibitor to Activator of T Cells with a Bispecific Tandem Single-Chain Fv Ligand" @default.
• W1571991353 cites W1485224098 @default.
• W1571991353 cites W1499540451 @default.
• W1571991353 cites W1537465465 @default.
• W1571991353 cites W1546040866 @default.
• W1571991353 cites W1557630270 @default.
• W1571991353 cites W1616993747 @default.
• W1571991353 cites W1624530503 @default.
• W1571991353 cites W1639242915 @default.
• W1571991353 cites W1852077611 @default.
• W1571991353 cites W1951252517 @default.
• W1571991353 cites W1965835906 @default.
• W1571991353 cites W1969219687 @default.
• W1571991353 cites W1973284926 @default.
• W1571991353 cites W1985516022 @default.
• W1571991353 cites W1988530230 @default.
• W1571991353 cites W1990718766 @default.
• W1571991353 cites W1994969460 @default.
• W1571991353 cites W1996228057 @default.
• W1571991353 cites W1996820981 @default.
• W1571991353 cites W1997546191 @default.
• W1571991353 cites W1999793253 @default.
• W1571991353 cites W2001640035 @default.
• W1571991353 cites W2001716606 @default.
• W1571991353 cites W2004281734 @default.
• W1571991353 cites W2004740475 @default.
• W1571991353 cites W2012338495 @default.
• W1571991353 cites W2012972418 @default.
• W1571991353 cites W2015090226 @default.
• W1571991353 cites W2042221539 @default.
• W1571991353 cites W2054153338 @default.
• W1571991353 cites W2065633276 @default.
• W1571991353 cites W2066234762 @default.
• W1571991353 cites W2069488204 @default.
• W1571991353 cites W2071483270 @default.
• W1571991353 cites W2078375925 @default.
• W1571991353 cites W2086224165 @default.
• W1571991353 cites W2090306908 @default.
• W1571991353 cites W2104874727 @default.
• W1571991353 cites W2105017308 @default.
• W1571991353 cites W2108599822 @default.
• W1571991353 cites W2116169737 @default.
• W1571991353 cites W2122700509 @default.
• W1571991353 cites W2124844952 @default.
• W1571991353 cites W2125322485 @default.
• W1571991353 cites W2132988697 @default.
• W1571991353 cites W2134738680 @default.
• W1571991353 cites W2137030947 @default.
• W1571991353 cites W2140460887 @default.
• W1571991353 cites W2141427930 @default.
• W1571991353 cites W2145080853 @default.
• W1571991353 cites W2146907765 @default.
• W1571991353 cites W2152812674 @default.
• W1571991353 cites W2152899663 @default.
• W1571991353 cites W2154837592 @default.
• W1571991353 cites W2159382428 @default.
• W1571991353 cites W2163391867 @default.
• W1571991353 cites W2166300495 @default.
• W1571991353 cites W2171026458 @default.
• W1571991353 cites W2312702847 @default.
• W1571991353 cites W4236694078 @default.
• W1571991353 cites W4240253200 @default.
• W1571991353 doi "https://doi.org/10.4049/jimmunol.172.10.5948" @default.
• W1571991353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15128776" @default.
• W1571991353 hasPublicationYear "2004" @default.
• W1571991353 type Work @default.
• W1571991353 sameAs 1571991353 @default.
• W1571991353 citedByCount "32" @default.
• W1571991353 countsByYear W15719913532012 @default.
• W1571991353 countsByYear W15719913532013 @default.
• W1571991353 countsByYear W15719913532014 @default.
• W1571991353 countsByYear W15719913532017 @default.
• W1571991353 countsByYear W15719913532019 @default.
• W1571991353 countsByYear W15719913532020 @default.
• W1571991353 crossrefType "journal-article" @default.
• W1571991353 hasAuthorship W1571991353A5000653097 @default.
• W1571991353 hasAuthorship W1571991353A5011133492 @default.
• W1571991353 hasAuthorship W1571991353A5019714017 @default.
• W1571991353 hasAuthorship W1571991353A5043749098 @default.
• W1571991353 hasAuthorship W1571991353A5056636501 @default.
• W1571991353 hasAuthorship W1571991353A5056785682 @default.
• W1571991353 hasAuthorship W1571991353A5064126401 @default.
• W1571991353 hasAuthorship W1571991353A5078013894 @default.
• W1571991353 hasBestOaLocation W15719913531 @default.
• W1571991353 hasConcept C104317684 @default.
• W1571991353 hasConcept C116569031 @default.

• next