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• W1577887552 abstract "Diabet. Med. 29, e170–e175 (2012) Abstract Aims To determine whether the frequency and severity of diabetic ketoacidosis and the clinical characteristics of children at diagnosis of Type 1 diabetes mellitus have changed over the past decades among patients under surveillance of a tertiary paediatric centre. Methods In three time‐periods, 75 (1986–1987), 86 (1996–1997) and 245 (2006–2007) patients at mean age 10.1 ± 4.7 years (0.6–20.0) were diagnosed with new‐onset Type 1 diabetes. Data on clinical characteristics and laboratory evaluation at diagnosis retrieved from the patients’ files . Comparative analysis was performed between the three time periods. Results The frequency of diabetic ketoacidosis at diagnosis was 40% in 1986–1987, 41.8% in 1996–1997 and 29.4% in 2006–2007; the last rate was significantly lower ( P = 0.04). No significant differences in the proportions of patients with severe or moderate diabetic ketoacidosis were found over time. Mean weight standard deviation score significantly increased from −0.72 ± 1.8 in 1986–1987 to −0.27 ± 1.2 in 2006–2007 ( P < 0.05), while percentage weight loss (∼6.5%) before diagnosis remained unchanged. In 2006–2007 a higher proportion of children had glucose testing at the community clinic before diagnosis, than in the earlier years (73.1 vs. 59.6%, P = 0.003). Conclusions The overall frequency of diabetic ketoacidosis in children with newly diagnosed Type 1 diabetes has decreased in the past decade, although the degree of metabolic decompensation has remained unchanged." @default.
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• W1577887552 date "2012-07-15" @default.
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• W1577887552 title "Decrease in frequency of ketoacidosis at diabetes onset over the past two decades - perspectives of a paediatric tertiary care centre" @default.
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• W1577887552 doi "https://doi.org/10.1111/j.1464-5491.2012.03679.x" @default.
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