FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1595584156> ?p ?o ?g. }

• W1595584156 endingPage "2507" @default.
• W1595584156 startingPage "2498" @default.
• W1595584156 abstract "Bone mineral density (BMD) is a major index for diagnosing osteoporosis. PhosSNPs are nonsynonymous SNPs that affect protein phosphorylation. The relevance and significance of phosSNPs to BMD and osteoporosis is unknown. This study aimed to identify and characterize phosSNPs significant for BMD in humans. We conducted a pilot genomewide phosSNP association study for BMD in three independent population samples, involving ∼5000 unrelated individuals. We identified and replicated three phosSNPs associated with both spine BMD and hip BMD in Caucasians. Association with hip BMD for one of these phosSNPs, ie, rs6265 (major/minor allele: G/A) in BDNF gene, was also suggested in Chinese. Consistently in both ethnicities, individuals carrying the AA genotype have significantly lower hip BMD than carriers of the GA and GG genotypes. Through in vitro molecular and cellular studies, we found that compared to osteoblastic cells transfected with wild-type BDNF-Val66 (encoded with allele G at rs6265), transfection of variant BDNF-Met66 (encoded with allele A at rs6265) significantly decreased BDNF protein phosphorylation (at amino acid residue T62), expression of osteoblastic genes (OPN, BMP2, and ALP), and osteoblastic activity. The findings are consistent with and explain our prior observations in general human populations. We conclude that phosSNP rs6265, by regulating BDNF protein phosphorylation and osteoblast differentiation, influences hip BMD in humans. This study represents our first endeavor to dissect the functions of phosSNPs in bone, which might stimulate extended large-scale studies on bone or similar studies on other human complex traits and diseases. © 2013 American Society for Bone and Mineral Research." @default.
• W1595584156 created "2016-06-24" @default.
• W1595584156 creator A5003083598 @default.
• W1595584156 creator A5006954610 @default.
• W1595584156 creator A5013518217 @default.
• W1595584156 creator A5014154811 @default.
• W1595584156 creator A5014890138 @default.
• W1595584156 creator A5025460672 @default.
• W1595584156 creator A5052883326 @default.
• W1595584156 creator A5053444102 @default.
• W1595584156 creator A5055342281 @default.
• W1595584156 creator A5072796826 @default.
• W1595584156 creator A5072824384 @default.
• W1595584156 date "2013-11-19" @default.
• W1595584156 modified "2023-09-30" @default.
• W1595584156 title "SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans" @default.
• W1595584156 cites W13948506 @default.
• W1595584156 cites W1488281632 @default.
• W1595584156 cites W1983816589 @default.
• W1595584156 cites W1986977063 @default.
• W1595584156 cites W1987946394 @default.
• W1595584156 cites W1995989434 @default.
• W1595584156 cites W1999091536 @default.
• W1595584156 cites W1999358563 @default.
• W1595584156 cites W2007156391 @default.
• W1595584156 cites W2011311044 @default.
• W1595584156 cites W2023940796 @default.
• W1595584156 cites W2037976986 @default.
• W1595584156 cites W2050285797 @default.
• W1595584156 cites W2053287079 @default.
• W1595584156 cites W2054985002 @default.
• W1595584156 cites W2065422950 @default.
• W1595584156 cites W2065766094 @default.
• W1595584156 cites W2067754245 @default.
• W1595584156 cites W2076378939 @default.
• W1595584156 cites W2086840459 @default.
• W1595584156 cites W2088869038 @default.
• W1595584156 cites W2106619210 @default.
• W1595584156 cites W2107889651 @default.
• W1595584156 cites W2127472226 @default.
• W1595584156 cites W2130417276 @default.
• W1595584156 cites W2133674956 @default.
• W1595584156 cites W2139565721 @default.
• W1595584156 cites W2161633633 @default.
• W1595584156 cites W2163144326 @default.
• W1595584156 cites W2168018233 @default.
• W1595584156 doi "https://doi.org/10.1002/jbmr.1997" @default.
• W1595584156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4127979" @default.
• W1595584156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23712400" @default.
• W1595584156 hasPublicationYear "2013" @default.
• W1595584156 type Work @default.
• W1595584156 sameAs 1595584156 @default.
• W1595584156 citedByCount "26" @default.
• W1595584156 countsByYear W15955841562014 @default.
• W1595584156 countsByYear W15955841562016 @default.
• W1595584156 countsByYear W15955841562017 @default.
• W1595584156 countsByYear W15955841562018 @default.
• W1595584156 countsByYear W15955841562019 @default.
• W1595584156 countsByYear W15955841562020 @default.
• W1595584156 countsByYear W15955841562021 @default.
• W1595584156 countsByYear W15955841562023 @default.
• W1595584156 crossrefType "journal-article" @default.
• W1595584156 hasAuthorship W1595584156A5003083598 @default.
• W1595584156 hasAuthorship W1595584156A5006954610 @default.
• W1595584156 hasAuthorship W1595584156A5013518217 @default.
• W1595584156 hasAuthorship W1595584156A5014154811 @default.
• W1595584156 hasAuthorship W1595584156A5014890138 @default.
• W1595584156 hasAuthorship W1595584156A5025460672 @default.
• W1595584156 hasAuthorship W1595584156A5052883326 @default.
• W1595584156 hasAuthorship W1595584156A5053444102 @default.
• W1595584156 hasAuthorship W1595584156A5055342281 @default.
• W1595584156 hasAuthorship W1595584156A5072796826 @default.
• W1595584156 hasAuthorship W1595584156A5072824384 @default.
• W1595584156 hasBestOaLocation W15955841561 @default.
• W1595584156 hasConcept C104317684 @default.
• W1595584156 hasConcept C126322002 @default.
• W1595584156 hasConcept C134018914 @default.
• W1595584156 hasConcept C135763542 @default.
• W1595584156 hasConcept C153209595 @default.
• W1595584156 hasConcept C157410074 @default.
• W1595584156 hasConcept C202751555 @default.
• W1595584156 hasConcept C2776541429 @default.
• W1595584156 hasConcept C2776886416 @default.
• W1595584156 hasConcept C2778163459 @default.
• W1595584156 hasConcept C2778260815 @default.
• W1595584156 hasConcept C2779329777 @default.
• W1595584156 hasConcept C2908647359 @default.
• W1595584156 hasConcept C54355233 @default.
• W1595584156 hasConcept C71924100 @default.
• W1595584156 hasConcept C86803240 @default.
• W1595584156 hasConcept C99454951 @default.
• W1595584156 hasConceptScore W1595584156C104317684 @default.
• W1595584156 hasConceptScore W1595584156C126322002 @default.
• W1595584156 hasConceptScore W1595584156C134018914 @default.
• W1595584156 hasConceptScore W1595584156C135763542 @default.
• W1595584156 hasConceptScore W1595584156C153209595 @default.
• W1595584156 hasConceptScore W1595584156C157410074 @default.
• W1595584156 hasConceptScore W1595584156C202751555 @default.

• next