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- W1693797750 abstract "Background Evolving lesions of lichen sclerosus ( LS ) pose a diagnostic challenge owing to an absence of classic findings of epidermal atrophy, dermal sclerosis, a band‐like lymphocytic infiltrate and the presence of eosinophils. Methods Retrospective specimens of LS were reviewed. Demographic information, biopsy vs. excision and the following histopathological characteristics were noted: presence and number of eosinophils, epidermal hyperplasia, spongiosis, early/transitional LS , well‐developed LS and coexisting squamous cell carcinoma ( SCC ). Linear regression analysis was performed. Results The data consisted of 66 biopsies (36 male [M], 30 female [F]), from 53 individuals ( 33M , 20F ), including 57 genital and 9 extragenital biopsies. Seven biopsies showed SCC , 28 showed epidermal hyperplasia and 14 exhibited spongiosis. Thirty‐five specimens were early/transitional LS and commonly exhibited epidermal hyperplasia (57%), epidermotropism of lymphocytes (97%) and basement membrane thickening (97%). Thirty‐five biopsies (53%) contained eosinophils (23 early/transitional lesions). Male gender (p = 0.074) was associated with increased eosinophils. The presence of SCC (p = 0.014) was a significant predictors of eosinophil number. Conclusions Epidermal hyperplasia, epidermotropism of lymphocytes and basement membrane thickening are helpful features in identifying early LS . Eosinophils are not an uncommon finding in LS and are most common in male genital lesions and in LS associated with SCC ." @default.
- W1693797750 created "2016-06-24" @default.
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- W1693797750 date "2014-12-11" @default.
- W1693797750 modified "2023-10-13" @default.
- W1693797750 title "Eosinophils in biopsy specimens of lichen sclerosus: a not uncommon finding" @default.
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- W1693797750 doi "https://doi.org/10.1111/cup.12445" @default.
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