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- W1701920108 abstract "Abstract ASD is a behaviorally defined syndrome and encompasses markedly heterogeneous subjects. Some ASD subjects reveal markedly fluctuating behavioral symptoms following immune insults and persistent gastrointestinal (GI) symptoms; categorized as the ASD-inflammatory subtype (ASD-IS) (N=20) in this study. Cyotkine production by purified PB monocytes from ASD-IS subjects in response to TLR2/6, TLR4, TLR7/8, and Dectin 1 agonists were assessed in comparison with cells from control ASD subjects with and without non-IgE mediated food allergy (NFA) (ASD/NFA N=16, ASD/non-NFA children; N=18), non-ASD controls (non-ASD/NFA; N=13, normal controls; N=12, non-ASD/PANS N=18). ASD-IS subjects had no siblings diagnosed with ASD and ASD-IS children are noted to have a higher frequency of recurrent sinopulmonary infection than ASD/non-ASD controls; 8/20 ASD-IS children were diagnosed with antibody deficiency syndrome (ADS). ASD-IS PB monocytes produced higher levels of IL-1β, IL-6, and IL-12 with or without stimuli. In addition, decrease in production of IL-10 and sTNFRII with TLR2/6 and TLR7/8 agonists was more striking than normal control monocytes. Monocytes from ASD/NFA, ASD/non-NFA, or non-ASD/NFA subjects did not reveal such tendencies. However, cytokine production by PANS monocytes revealed similar tendencies. Aberrant innate immune responses detected in PB monocytes may be associated with markedly fluctuating neuropsychiatric symptoms observed in ASD-IS and PANS subjects." @default.
- W1701920108 created "2016-06-24" @default.
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- W1701920108 date "2014-05-01" @default.
- W1701920108 modified "2023-10-16" @default.
- W1701920108 title "Peripheral blood (PB) monocytes from subjects with autism spectrum disorders (ASD) and fluctuating behavioral symptoms following immune insults reveal similar innate immune responses to those observed in pediatric acute onset neuropsychiatric disorders (PANS). (HUM1P.325)" @default.
- W1701920108 doi "https://doi.org/10.4049/jimmunol.192.supp.52.25" @default.
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