Matches in SemOpenAlex for { <https://semopenalex.org/work/W170993180> ?p ?o ?g. }
- W170993180 endingPage "674" @default.
- W170993180 startingPage "633" @default.
- W170993180 abstract "Although the human genome encodes many membrane transporters, relatively few (~ 20) are drug transporters involved in the disposition of drugs. Modern drug discovery and development is experiencing a major paradigm shift in using chemicals that are hydrophilic and polar, resulting in the selection of poorly permeable compounds. This class of compounds relies on drug transporters to enter the target organs. The strategic localization of drug transporters regulates tissue-specific concentrations for many substrate drugs. However, the organ-specific disposition of drugs is not accurately determined by the concentrations clinically measured in plasma. Pathophysiological processes are required for cell survival and are often associated with the malfunction of membrane transporters. Drug transporters are involved in organ toxicity through different mechanisms, which is an important consideration in drug discovery. Due to compelling clinical evidence of transporter-related DDIs, current regulatory guidance requires that interactions with seven core transporters, OATP1B1/1B3, OAT1/3, OCT2, P-gp and BCRP, are tested. Two additional transporters, OCT1 and BSEP, are included in the guidance of the European Medicines Agency (EMA) due to the important role of these proteins in the efficacy of metformin and in bile salt homeostasis, respectively." @default.
- W170993180 created "2016-06-24" @default.
- W170993180 creator A5032674117 @default.
- W170993180 creator A5058112913 @default.
- W170993180 date "2013-01-01" @default.
- W170993180 modified "2023-10-17" @default.
- W170993180 title "Drug transporters in drug discovery and development" @default.
- W170993180 cites W1486126828 @default.
- W170993180 cites W1501531697 @default.
- W170993180 cites W1502459074 @default.
- W170993180 cites W1528647023 @default.
- W170993180 cites W1557510459 @default.
- W170993180 cites W1558276030 @default.
- W170993180 cites W1604547439 @default.
- W170993180 cites W1605451242 @default.
- W170993180 cites W1783939843 @default.
- W170993180 cites W1788032165 @default.
- W170993180 cites W1836899377 @default.
- W170993180 cites W1853241466 @default.
- W170993180 cites W1901833910 @default.
- W170993180 cites W1903015803 @default.
- W170993180 cites W1964471078 @default.
- W170993180 cites W1964511612 @default.
- W170993180 cites W1965477067 @default.
- W170993180 cites W1966440700 @default.
- W170993180 cites W1968468357 @default.
- W170993180 cites W1969949427 @default.
- W170993180 cites W1970263371 @default.
- W170993180 cites W1971182486 @default.
- W170993180 cites W1971901938 @default.
- W170993180 cites W1972056241 @default.
- W170993180 cites W1975586649 @default.
- W170993180 cites W1975971473 @default.
- W170993180 cites W1976169273 @default.
- W170993180 cites W1976334395 @default.
- W170993180 cites W1982640074 @default.
- W170993180 cites W1983184704 @default.
- W170993180 cites W1985657228 @default.
- W170993180 cites W1986694485 @default.
- W170993180 cites W1987305063 @default.
- W170993180 cites W1987857738 @default.
- W170993180 cites W1990932902 @default.
- W170993180 cites W1991652499 @default.
- W170993180 cites W1992009633 @default.
- W170993180 cites W1992918939 @default.
- W170993180 cites W1995500412 @default.
- W170993180 cites W1996271706 @default.
- W170993180 cites W1996985091 @default.
- W170993180 cites W1997696660 @default.
- W170993180 cites W1999004536 @default.
- W170993180 cites W2000753827 @default.
- W170993180 cites W2003455288 @default.
- W170993180 cites W2004785370 @default.
- W170993180 cites W2005518854 @default.
- W170993180 cites W2005531240 @default.
- W170993180 cites W2006821380 @default.
- W170993180 cites W2007052092 @default.
- W170993180 cites W2007776961 @default.
- W170993180 cites W2008058849 @default.
- W170993180 cites W2010063142 @default.
- W170993180 cites W2010241890 @default.
- W170993180 cites W2012021913 @default.
- W170993180 cites W2013793754 @default.
- W170993180 cites W2014593961 @default.
- W170993180 cites W2015354385 @default.
- W170993180 cites W2018126221 @default.
- W170993180 cites W2020059317 @default.
- W170993180 cites W2020196369 @default.
- W170993180 cites W2020441233 @default.
- W170993180 cites W2022545732 @default.
- W170993180 cites W2028533496 @default.
- W170993180 cites W2028615902 @default.
- W170993180 cites W2030099120 @default.
- W170993180 cites W2030419995 @default.
- W170993180 cites W2030763326 @default.
- W170993180 cites W2031595392 @default.
- W170993180 cites W2031896095 @default.
- W170993180 cites W2032601679 @default.
- W170993180 cites W2034200280 @default.
- W170993180 cites W2034886511 @default.
- W170993180 cites W2036682576 @default.
- W170993180 cites W2037983445 @default.
- W170993180 cites W2038319468 @default.
- W170993180 cites W2040411965 @default.
- W170993180 cites W2041763597 @default.
- W170993180 cites W2042721486 @default.
- W170993180 cites W2044938527 @default.
- W170993180 cites W2045689507 @default.
- W170993180 cites W2046976450 @default.
- W170993180 cites W2048192376 @default.
- W170993180 cites W2048593300 @default.
- W170993180 cites W2049390540 @default.
- W170993180 cites W2049645697 @default.
- W170993180 cites W2050395450 @default.
- W170993180 cites W2050402229 @default.
- W170993180 cites W2052888437 @default.
- W170993180 cites W2053422488 @default.
- W170993180 cites W2053545020 @default.