FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1723250024> ?p ?o ?g. }

• W1723250024 abstract "In moderately diabetic rats (plasma glucose 20 – 30 mmol/L), where there is some residual pancreatic islet function, normoglycemia can be restored by transplantation of pancreatic islets into the liver via the portal vein. To examine whether normoglycemia can also be achieved in more severely diabetic animals (which more closely resemble human type I diabetes), we have compared the effect of transplanting 1000 islets intraportally in Lewis rats made moderately diabetic (55 mg/kg streptozotocin injected IP while nonfasting) or severely diabetic (65 mg/kg streptozotocin injected IP while fasting). In the moderately diabetic rats in which residual pancreatic insulin was 128 ± 40 mU insulin (2.0% of control), plasma glucose stabilized (32 ± 2.8 mmol/L at 1 week, 34 ± 2 mmol/L at 3 weeks) as did body weight (falling from 290 ± 5 to 265 ± 5 g at 1 week and 253 ± 6 g at 3 weeks). In contrast, in severely diabetic rats in which residual pancreatic insulin was only 13.5 ± 4.2 mU insulin (0.21% of control), there was a progressive rise in plasma glucose (30 ± 1.3 mmol/L at 1 week, 49 ± 4 mmol/L at 2 weeks, and 67 ± 7 mmol/L at 3 weeks) and a progressive fall in body weight (from 304 ± 10 to 260 ± 5 g by week 1 and to 209 ± 6 g by week 3). Following islet transplantation, nonfasting plasma glucose normalized in moderately diabetic rats (10.5 ± 0.6 vs. 9.1 ± 0.6 mmol/L in nondiabetic controls, NS) after 23 ± 5 days. In contrast, in the severely diabetic rats plasma glucose stabilized at 32 ± 5mmol/L (p < 0.05 compared to moderately diabetic group) but did not normalize. This difference was not attributable to different plasma glucose levels at the time of transplantation (35.1 ± 1.8 in moderately diabetic vs. 32.5 ± 2.5 mmol/L in severely diabetic rats). These observations demonstrate that residual native β-cells (equivalent to only 60 – 80 islets) contribute to the survival or function of intraportally transplanted islets." @default.
• W1723250024 created "2016-06-24" @default.
• W1723250024 creator A5010854241 @default.
• W1723250024 creator A5036697824 @default.
• W1723250024 creator A5091210533 @default.
• W1723250024 date "2001-03-01" @default.
• W1723250024 modified "2023-09-26" @default.
• W1723250024 title "Surviving Native β-Cells Determine Outcome of Syngeneic Intraportal Islet Transplantation" @default.
• W1723250024 cites W1970733173 @default.
• W1723250024 cites W1973494475 @default.
• W1723250024 cites W1979096558 @default.
• W1723250024 cites W1985938279 @default.
• W1723250024 cites W1988103735 @default.
• W1723250024 cites W1991729716 @default.
• W1723250024 cites W2002031561 @default.
• W1723250024 cites W2005845118 @default.
• W1723250024 cites W2005975977 @default.
• W1723250024 cites W2012659203 @default.
• W1723250024 cites W2013863745 @default.
• W1723250024 cites W2027161267 @default.
• W1723250024 cites W2035055926 @default.
• W1723250024 cites W2053681600 @default.
• W1723250024 cites W2059716312 @default.
• W1723250024 cites W2066797434 @default.
• W1723250024 cites W2068382452 @default.
• W1723250024 cites W2087208178 @default.
• W1723250024 cites W2092147268 @default.
• W1723250024 cites W2092162739 @default.
• W1723250024 cites W2131817617 @default.
• W1723250024 cites W2153805312 @default.
• W1723250024 cites W2164695685 @default.
• W1723250024 cites W2169550514 @default.
• W1723250024 cites W4237978080 @default.
• W1723250024 doi "https://doi.org/10.3727/000000001783986846" @default.
• W1723250024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11332628" @default.
• W1723250024 hasPublicationYear "2001" @default.
• W1723250024 type Work @default.
• W1723250024 sameAs 1723250024 @default.
• W1723250024 citedByCount "7" @default.
• W1723250024 countsByYear W17232500242014 @default.
• W1723250024 crossrefType "journal-article" @default.
• W1723250024 hasAuthorship W1723250024A5010854241 @default.
• W1723250024 hasAuthorship W1723250024A5036697824 @default.
• W1723250024 hasAuthorship W1723250024A5091210533 @default.
• W1723250024 hasBestOaLocation W17232500241 @default.
• W1723250024 hasConcept C126322002 @default.
• W1723250024 hasConcept C134018914 @default.
• W1723250024 hasConcept C165220095 @default.
• W1723250024 hasConcept C2779280383 @default.
• W1723250024 hasConcept C2779306644 @default.
• W1723250024 hasConcept C2779855799 @default.
• W1723250024 hasConcept C2911091166 @default.
• W1723250024 hasConcept C555293320 @default.
• W1723250024 hasConcept C71924100 @default.
• W1723250024 hasConceptScore W1723250024C126322002 @default.
• W1723250024 hasConceptScore W1723250024C134018914 @default.
• W1723250024 hasConceptScore W1723250024C165220095 @default.
• W1723250024 hasConceptScore W1723250024C2779280383 @default.
• W1723250024 hasConceptScore W1723250024C2779306644 @default.
• W1723250024 hasConceptScore W1723250024C2779855799 @default.
• W1723250024 hasConceptScore W1723250024C2911091166 @default.
• W1723250024 hasConceptScore W1723250024C555293320 @default.
• W1723250024 hasConceptScore W1723250024C71924100 @default.
• W1723250024 hasLocation W17232500241 @default.
• W1723250024 hasLocation W17232500242 @default.
• W1723250024 hasOpenAccess W1723250024 @default.
• W1723250024 hasPrimaryLocation W17232500241 @default.
• W1723250024 hasRelatedWork W1966215579 @default.
• W1723250024 hasRelatedWork W1979477971 @default.
• W1723250024 hasRelatedWork W2019527973 @default.
• W1723250024 hasRelatedWork W2025485770 @default.
• W1723250024 hasRelatedWork W2050186243 @default.
• W1723250024 hasRelatedWork W2077192432 @default.
• W1723250024 hasRelatedWork W2092545538 @default.
• W1723250024 hasRelatedWork W2093521954 @default.
• W1723250024 hasRelatedWork W2115830754 @default.
• W1723250024 hasRelatedWork W2115874869 @default.
• W1723250024 hasRelatedWork W2118041795 @default.
• W1723250024 hasRelatedWork W2119186903 @default.
• W1723250024 hasRelatedWork W2146529656 @default.
• W1723250024 hasRelatedWork W2157604930 @default.
• W1723250024 hasRelatedWork W2157821534 @default.
• W1723250024 hasRelatedWork W2159317318 @default.
• W1723250024 hasRelatedWork W2328786770 @default.
• W1723250024 hasRelatedWork W2360462325 @default.
• W1723250024 hasRelatedWork W2380848221 @default.
• W1723250024 hasRelatedWork W2394972792 @default.
• W1723250024 isParatext "false" @default.
• W1723250024 isRetracted "false" @default.
• W1723250024 magId "1723250024" @default.
• W1723250024 workType "article" @default.