Matches in SemOpenAlex for { <https://semopenalex.org/work/W1738931535> ?p ?o ?g. }
- W1738931535 endingPage "661" @default.
- W1738931535 startingPage "644" @default.
- W1738931535 abstract "Protein phosphatase type 2A (PP2A) enzymes constitute a large family of Ser/Thr phosphatases with multiple functions in cellular signaling and physiology. The composition of heterotrimeric PP2A holoenzymes, resulting from the combinatorial assembly of a catalytic C subunit, a structural A subunit, and regulatory B-type subunit, provides the essential determinants for substrate specificity, subcellular targeting, and fine-tuning of phosphatase activity, largely explaining why PP2A is functionally involved in so many diverse physiological processes, sometimes in seemingly opposing ways. In this review, we highlight how PP2A holoenzyme biogenesis and enzymatic activity are controlled by a sophisticatedly coordinated network of five PP2A modulators, consisting of α4, phosphatase 2A phosphatase activator (PTPA), leucine carboxyl methyl transferase 1 (LCMT1), PP2A methyl esterase 1 (PME-1) and, potentially, target of rapamycin signaling pathway regulator-like 1 (TIPRL1), which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. Likewise, these modulators may come into play when PP2A holoenzymes are disassembled following particular cellular stresses. Malfunctioning of these cellular control mechanisms contributes to human disease. The potential therapeutic benefits or pitfalls of interfering with these regulatory mechanisms will be briefly discussed." @default.
- W1738931535 created "2016-06-24" @default.
- W1738931535 creator A5009039747 @default.
- W1738931535 creator A5025164863 @default.
- W1738931535 creator A5052092471 @default.
- W1738931535 creator A5069137118 @default.
- W1738931535 creator A5091302888 @default.
- W1738931535 date "2012-04-25" @default.
- W1738931535 modified "2023-10-16" @default.
- W1738931535 title "The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity" @default.
- W1738931535 cites W1491963484 @default.
- W1738931535 cites W1516912887 @default.
- W1738931535 cites W1576464279 @default.
- W1738931535 cites W1598855117 @default.
- W1738931535 cites W1602452181 @default.
- W1738931535 cites W195118146 @default.
- W1738931535 cites W1964499404 @default.
- W1738931535 cites W1964893196 @default.
- W1738931535 cites W1968157723 @default.
- W1738931535 cites W1971335607 @default.
- W1738931535 cites W1971396436 @default.
- W1738931535 cites W1972236331 @default.
- W1738931535 cites W1976843330 @default.
- W1738931535 cites W1977599918 @default.
- W1738931535 cites W1981076681 @default.
- W1738931535 cites W1981751137 @default.
- W1738931535 cites W1981831836 @default.
- W1738931535 cites W1983744843 @default.
- W1738931535 cites W1986492134 @default.
- W1738931535 cites W1988862655 @default.
- W1738931535 cites W1990049897 @default.
- W1738931535 cites W1990396454 @default.
- W1738931535 cites W1990643576 @default.
- W1738931535 cites W1992049648 @default.
- W1738931535 cites W1994992878 @default.
- W1738931535 cites W1995245374 @default.
- W1738931535 cites W1996655478 @default.
- W1738931535 cites W1997538265 @default.
- W1738931535 cites W1997664222 @default.
- W1738931535 cites W1998681857 @default.
- W1738931535 cites W2000555456 @default.
- W1738931535 cites W2002569752 @default.
- W1738931535 cites W2003424246 @default.
- W1738931535 cites W2004361019 @default.
- W1738931535 cites W2005418171 @default.
- W1738931535 cites W2005939142 @default.
- W1738931535 cites W2010522496 @default.
- W1738931535 cites W2011159058 @default.
- W1738931535 cites W2012819402 @default.
- W1738931535 cites W2013947447 @default.
- W1738931535 cites W2014306255 @default.
- W1738931535 cites W2016510291 @default.
- W1738931535 cites W2017092095 @default.
- W1738931535 cites W2021386082 @default.
- W1738931535 cites W2026332814 @default.
- W1738931535 cites W2028083348 @default.
- W1738931535 cites W2029297782 @default.
- W1738931535 cites W2030633377 @default.
- W1738931535 cites W2031442396 @default.
- W1738931535 cites W2031853870 @default.
- W1738931535 cites W2032367079 @default.
- W1738931535 cites W2032896827 @default.
- W1738931535 cites W2032966848 @default.
- W1738931535 cites W2034031817 @default.
- W1738931535 cites W2034102482 @default.
- W1738931535 cites W2040038307 @default.
- W1738931535 cites W2041171080 @default.
- W1738931535 cites W2044419584 @default.
- W1738931535 cites W2044830832 @default.
- W1738931535 cites W2046079854 @default.
- W1738931535 cites W2048159541 @default.
- W1738931535 cites W2049961020 @default.
- W1738931535 cites W2050703700 @default.
- W1738931535 cites W2051869227 @default.
- W1738931535 cites W2052875624 @default.
- W1738931535 cites W2053075955 @default.
- W1738931535 cites W2054221542 @default.
- W1738931535 cites W2057593147 @default.
- W1738931535 cites W2060770087 @default.
- W1738931535 cites W2063123880 @default.
- W1738931535 cites W2063618925 @default.
- W1738931535 cites W2066893159 @default.
- W1738931535 cites W2067056140 @default.
- W1738931535 cites W2067127659 @default.
- W1738931535 cites W2074455749 @default.
- W1738931535 cites W2074680571 @default.
- W1738931535 cites W2077007207 @default.
- W1738931535 cites W2077038948 @default.
- W1738931535 cites W2077828161 @default.
- W1738931535 cites W2078566826 @default.
- W1738931535 cites W2079933835 @default.
- W1738931535 cites W2079975524 @default.
- W1738931535 cites W2081593830 @default.
- W1738931535 cites W2083951294 @default.
- W1738931535 cites W2084352760 @default.
- W1738931535 cites W2084573676 @default.
- W1738931535 cites W2084623733 @default.
- W1738931535 cites W2087366857 @default.