FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750867529> ?p ?o ?g. }

• W1750867529 endingPage "4242" @default.
• W1750867529 startingPage "4229" @default.
• W1750867529 abstract "Research Article1 November 1993free access More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. I. Bach I. Bach Unité des Virus Oncogènes, UA 1644 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France. Search for more papers by this author M. Yaniv M. Yaniv Unité des Virus Oncogènes, UA 1644 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France. Search for more papers by this author I. Bach I. Bach Unité des Virus Oncogènes, UA 1644 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France. Search for more papers by this author M. Yaniv M. Yaniv Unité des Virus Oncogènes, UA 1644 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France. Search for more papers by this author Author Information I. Bach1 and M. Yaniv1 1Unité des Virus Oncogènes, UA 1644 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France. The EMBO Journal (1993)12:4229-4242https://doi.org/10.1002/j.1460-2075.1993.tb06107.x Correction(s) for this article CorrigendumJanuary 1994 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We report the isolation of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing. In the novel isoforms intron sequences that are excised in the previously described forms are translated in the same frame as exon sequences until the first termination codon is encountered. Hence, the newly found isoforms all contain different C-terminal domains. For HNF1 it has been shown that its C-terminal region is responsible for the activation of transcription. In transient transfection assays the two novel HNF1 isoforms, HNF1-B and -C, transactivate 5-fold better than the previously described HNF1 protein (HNF1-A). The newly isolated isoform of vHNF1, designated vHNF1-C, is unable to transactivate and behaves as a transdominant repressor when cotransfected with HNF1-A, -B or -C. All of the different isoforms of HNF1 and vHNF1 can form homo- and heterodimers and their mRNAs are differentially expressed in fetal and adult human liver, kidney and intestine, suggesting distinct roles during development. Our studies show that the transactivation domain of the members of the HNF1 homeoprotein family is organized in modules which can be exchanged to generate either more potent transcriptional activators or a transdominant repressor. Previous ArticleNext Article Volume 12Issue 111 November 1993In this issue RelatedDetailsLoading ..." @default.
• W1750867529 created "2016-06-24" @default.
• W1750867529 creator A5034369141 @default.
• W1750867529 creator A5043603982 @default.
• W1750867529 date "1993-11-01" @default.
• W1750867529 modified "2023-09-25" @default.
• W1750867529 title "More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing." @default.
• W1750867529 cites W1034404286 @default.
• W1750867529 cites W1528390238 @default.
• W1750867529 cites W1543700757 @default.
• W1750867529 cites W1559932979 @default.
• W1750867529 cites W1755110012 @default.
• W1750867529 cites W1799486566 @default.
• W1750867529 cites W1834912150 @default.
• W1750867529 cites W1846817913 @default.
• W1750867529 cites W1963704405 @default.
• W1750867529 cites W1965048899 @default.
• W1750867529 cites W1965258786 @default.
• W1750867529 cites W1969809090 @default.
• W1750867529 cites W1971263640 @default.
• W1750867529 cites W1974217132 @default.
• W1750867529 cites W1976150837 @default.
• W1750867529 cites W1981286265 @default.
• W1750867529 cites W1983276757 @default.
• W1750867529 cites W1991481988 @default.
• W1750867529 cites W1994738496 @default.
• W1750867529 cites W1996339709 @default.
• W1750867529 cites W1996831533 @default.
• W1750867529 cites W2009862260 @default.
• W1750867529 cites W2011957289 @default.
• W1750867529 cites W2013076780 @default.
• W1750867529 cites W2017615910 @default.
• W1750867529 cites W2018289835 @default.
• W1750867529 cites W2021334674 @default.
• W1750867529 cites W2031611773 @default.
• W1750867529 cites W2033322554 @default.
• W1750867529 cites W2047842452 @default.
• W1750867529 cites W2049672602 @default.
• W1750867529 cites W2050836341 @default.
• W1750867529 cites W2051277201 @default.
• W1750867529 cites W2062423659 @default.
• W1750867529 cites W2075256977 @default.
• W1750867529 cites W2080132636 @default.
• W1750867529 cites W2086787966 @default.
• W1750867529 cites W2086950550 @default.
• W1750867529 cites W2087288778 @default.
• W1750867529 cites W2088335423 @default.
• W1750867529 cites W2089398626 @default.
• W1750867529 cites W2090467716 @default.
• W1750867529 cites W2101108802 @default.
• W1750867529 cites W2103885797 @default.
• W1750867529 cites W2109170983 @default.
• W1750867529 cites W2114683402 @default.
• W1750867529 cites W2117288635 @default.
• W1750867529 cites W2117969708 @default.
• W1750867529 cites W2124947814 @default.
• W1750867529 cites W2127856551 @default.
• W1750867529 cites W2130577528 @default.
• W1750867529 cites W2134812217 @default.
• W1750867529 cites W2143464311 @default.
• W1750867529 cites W2144715892 @default.
• W1750867529 cites W2411724679 @default.
• W1750867529 cites W2425167846 @default.
• W1750867529 cites W287412083 @default.
• W1750867529 cites W295339133 @default.
• W1750867529 cites W65082297 @default.
• W1750867529 cites W79384053 @default.
• W1750867529 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06107.x" @default.
• W1750867529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413717" @default.
• W1750867529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7900999" @default.
• W1750867529 hasPublicationYear "1993" @default.
• W1750867529 type Work @default.
• W1750867529 sameAs 1750867529 @default.
• W1750867529 citedByCount "118" @default.
• W1750867529 countsByYear W17508675292012 @default.
• W1750867529 countsByYear W17508675292013 @default.
• W1750867529 countsByYear W17508675292014 @default.
• W1750867529 countsByYear W17508675292015 @default.
• W1750867529 countsByYear W17508675292016 @default.
• W1750867529 countsByYear W17508675292017 @default.
• W1750867529 countsByYear W17508675292018 @default.
• W1750867529 countsByYear W17508675292021 @default.
• W1750867529 countsByYear W17508675292022 @default.
• W1750867529 countsByYear W17508675292023 @default.
• W1750867529 crossrefType "journal-article" @default.
• W1750867529 hasAuthorship W1750867529A5034369141 @default.
• W1750867529 hasAuthorship W1750867529A5043603982 @default.
• W1750867529 hasBestOaLocation W17508675291 @default.
• W1750867529 hasConcept C104317684 @default.
• W1750867529 hasConcept C153911025 @default.
• W1750867529 hasConcept C194583182 @default.
• W1750867529 hasConcept C36823959 @default.
• W1750867529 hasConcept C54355233 @default.
• W1750867529 hasConcept C54458228 @default.
• W1750867529 hasConcept C67705224 @default.
• W1750867529 hasConcept C86803240 @default.
• W1750867529 hasConcept C94671646 @default.
• W1750867529 hasConceptScore W1750867529C104317684 @default.

• next