Matches in SemOpenAlex for { <https://semopenalex.org/work/W179618825> ?p ?o ?g. }
- W179618825 endingPage "760" @default.
- W179618825 startingPage "745" @default.
- W179618825 abstract "This chapter discusses mechanosensitive (MS) ion channels in eukaryotic cells. MS channels are ubiquitous, abundant, and diverse. The chapter also refers briefly to the genetic and molecular work. It is mentioned that MS channel breakthroughs have occurred on three fronts over the last half decade—electrophysiologic, genetic, and molecular. The chapter includes list of the criteria MS channel performing a mechanical cellular task by Morris (1992). The criteria that need to be met can be compared to those that have been met by ligand-gated and voltage-gated channels with established physiological roles. The discussion of explorations of MS channels includes fungal germling of bean rust, Xenopus oocytes MS channels, NMDA (glutamate) channels in mouse neurons, and others. For single-channel recordings, the name MS channel carries an implicit assumption that some susceptible gating structure experiences tension in the plane of the membrane and that this biases the channel's open probability. The available information on possible mechanisms of ion channel mechanosensitivity suggests that both the extremes are important. At one extreme, the specialized receptors, cytoarchitecture is central to function. At the other extreme are bacterial MS channels, which can be reconstituted into artificial bilayers and retain their mechanosensitivity. The term MS channel may be reserved for physiological mechanotransducer channels. Although MS channels detectable at the single-channel level have been on the scene for almost two decades, they should only be afforded a status coequal with voltage-gated and ligand-gated channels once it is abundantly clear that their MS gating has a biological meaning. The chapter concludes by stating that the inherent mechanosusceptibility of many other channels also acquires biological meaning (rather than solely biophysical meaning), if it is shown that evolution has had to look for ways to protect cells from unwanted mechanically driven membrane currents." @default.
- W179618825 created "2016-06-24" @default.
- W179618825 creator A5070995015 @default.
- W179618825 date "2001-01-01" @default.
- W179618825 modified "2023-10-16" @default.
- W179618825 title "Mechanosensitive Ion Channels in Eukaryotic Cells" @default.
- W179618825 cites W145759849 @default.
- W179618825 cites W1531796828 @default.
- W179618825 cites W1536281405 @default.
- W179618825 cites W1541419413 @default.
- W179618825 cites W1550607465 @default.
- W179618825 cites W1553432978 @default.
- W179618825 cites W1579765465 @default.
- W179618825 cites W1626382598 @default.
- W179618825 cites W1761198925 @default.
- W179618825 cites W1814044618 @default.
- W179618825 cites W1965209261 @default.
- W179618825 cites W1967755760 @default.
- W179618825 cites W1970770580 @default.
- W179618825 cites W1971642414 @default.
- W179618825 cites W1981562838 @default.
- W179618825 cites W1982361983 @default.
- W179618825 cites W1990859310 @default.
- W179618825 cites W1994929421 @default.
- W179618825 cites W1995103743 @default.
- W179618825 cites W1998563463 @default.
- W179618825 cites W2000998004 @default.
- W179618825 cites W2004308959 @default.
- W179618825 cites W2006202751 @default.
- W179618825 cites W2007168806 @default.
- W179618825 cites W2007514006 @default.
- W179618825 cites W2007665141 @default.
- W179618825 cites W2009304256 @default.
- W179618825 cites W2015901891 @default.
- W179618825 cites W2016532047 @default.
- W179618825 cites W2017832591 @default.
- W179618825 cites W2017972049 @default.
- W179618825 cites W2019121351 @default.
- W179618825 cites W2019129862 @default.
- W179618825 cites W2020149988 @default.
- W179618825 cites W2023297178 @default.
- W179618825 cites W2023918660 @default.
- W179618825 cites W2025720625 @default.
- W179618825 cites W2029305793 @default.
- W179618825 cites W2029760412 @default.
- W179618825 cites W2032023073 @default.
- W179618825 cites W2032380727 @default.
- W179618825 cites W2047518846 @default.
- W179618825 cites W2051877951 @default.
- W179618825 cites W2053670566 @default.
- W179618825 cites W2054600929 @default.
- W179618825 cites W2058658678 @default.
- W179618825 cites W2062912208 @default.
- W179618825 cites W2068267969 @default.
- W179618825 cites W2075451326 @default.
- W179618825 cites W2075672949 @default.
- W179618825 cites W2078276507 @default.
- W179618825 cites W2083457444 @default.
- W179618825 cites W2085725615 @default.
- W179618825 cites W2091410842 @default.
- W179618825 cites W2092000405 @default.
- W179618825 cites W2092442184 @default.
- W179618825 cites W2092920907 @default.
- W179618825 cites W2097296613 @default.
- W179618825 cites W2098588948 @default.
- W179618825 cites W2101626632 @default.
- W179618825 cites W2106601754 @default.
- W179618825 cites W2114367454 @default.
- W179618825 cites W2119595362 @default.
- W179618825 cites W2124969505 @default.
- W179618825 cites W2125942201 @default.
- W179618825 cites W2143842176 @default.
- W179618825 cites W2146960955 @default.
- W179618825 cites W2147869016 @default.
- W179618825 cites W2154939910 @default.
- W179618825 cites W2157194890 @default.
- W179618825 cites W2409505590 @default.
- W179618825 cites W2410720366 @default.
- W179618825 cites W2987371451 @default.
- W179618825 cites W301021055 @default.
- W179618825 cites W4240352020 @default.
- W179618825 cites W4250617951 @default.
- W179618825 doi "https://doi.org/10.1016/b978-012656976-6/50136-0" @default.
- W179618825 hasPublicationYear "2001" @default.
- W179618825 type Work @default.
- W179618825 sameAs 179618825 @default.
- W179618825 citedByCount "6" @default.
- W179618825 crossrefType "book-chapter" @default.
- W179618825 hasAuthorship W179618825A5070995015 @default.
- W179618825 hasConcept C104317684 @default.
- W179618825 hasConcept C12554922 @default.
- W179618825 hasConcept C127162648 @default.
- W179618825 hasConcept C169760540 @default.
- W179618825 hasConcept C170493617 @default.
- W179618825 hasConcept C178790620 @default.
- W179618825 hasConcept C181911157 @default.
- W179618825 hasConcept C185592680 @default.
- W179618825 hasConcept C194544171 @default.