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- W1834972362 abstract "Significance The juvenile–adult transition is a key developmental process in organisms. A long-held paradigm in insect endocrinology is that juvenile hormones (JHs) prevent metamorphosis until larvae attain an appropriate size for the juvenile–adult transition. However, little is known about the roles for JHs during embryonic and very early larval stages. We established knockouts of the silkworm, a classic model insect, and show that embryogenesis and maintenance of juvenile status during the early larval stages are largely independent of JHs or the JH-signaling pathway. Our results also suggest that an unidentified factor or signal is required to acquire the competence for metamorphosis. The presence of this factor has long been overlooked because JHs may conceal its action." @default.
- W1834972362 created "2016-06-24" @default.
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- W1834972362 date "2015-07-20" @default.
- W1834972362 modified "2023-10-18" @default.
- W1834972362 title "Knockout silkworms reveal a dispensable role for juvenile hormones in holometabolous life cycle" @default.
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- W1834972362 doi "https://doi.org/10.1073/pnas.1506645112" @default.
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