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• W1845820893 abstract "Recently, several genome-wide association studies have demonstrated an association between endometriosis and markers located in or near to WNT4 gene. In order to assess the validity of the findings, we conducted a replication case-control study in a Brazilian population.Genetic association study comprising 400 infertile women with endometriosis and 400 fertile women as controls. TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single-nucleotide polymorphisms (rs16826658, rs3820282, rs2235529, and rs7521902) in WNT4 gene. Genotype distribution, allele frequency, and haplotype analysis of the WNT4 polymorphisms were performed. A p value <0.05 was considered significant.The results revealed a significant association of rs16826658 (p = 7e-04) and rs3820282 (p = 0.048) single-nucleotide polymorphisms (SNPs) on WNT4 gene with endometriosis-related infertility, while rs2235529 and rs7521902 SNPs showed no difference between cases and controls.Our results suggested that rs16826658 and rs3820282 polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women studied. Analysis of WNT4 genetic variants might help to identify patients at high risk for disease development." @default.
• W1845820893 created "2016-06-24" @default.
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• W1845820893 date "2015-07-03" @default.
• W1845820893 modified "2023-09-27" @default.
• W1845820893 title "Association of WNT4 polymorphisms with endometriosis in infertile patients" @default.
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• W1845820893 doi "https://doi.org/10.1007/s10815-015-0523-1" @default.
• W1845820893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4595394" @default.
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• W1845820893 hasPublicationYear "2015" @default.
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