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- W1858225552 abstract "This chapter emphasizes some of the recent findings related to the mechanisms that regulate cholesterol synthesis and the catabolism of cholesterol to bile acids and discusses the studies that have demonstrated that certain polyisoprenoids, including farnesyl pyrophosphate, an intermediate in sterol synthesis, are involved in the important posttranslational modification of a number of proteins. All mammalian cells obtain cholesterol via at least three different routes: by de novo synthesis or by uptake of extracellular cholesterol-rich lipoproteins either via a specific regulated pathway or a nonspecific, nonregulated process, termed pinocytosis. The identification of the physiological regulatory sterol and the role it plays in controlling gene transcription is also of paramount importance. The recent cloning of cholesterol 7a-hydroxylase and the sterol 26-hydroxylase should allow investigators to begin dissecting the mechanisms controlling bile acid synthesis and defects in this pathway. However, many questions remain to be answered that relate to the mechanisms involved in the control of cholesterol and bile acid synthesis, such as where is reductase degraded and what triggers the process." @default.
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- W1858225552 date "1991-01-01" @default.
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- W1858225552 title "Chapter 13 Regulation of sterol biosynthesis and isoprenylation of proteins" @default.
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- W1858225552 doi "https://doi.org/10.1016/s0167-7306(08)60341-5" @default.
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