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- W189819871 abstract "textabstractThe tripeptide TRH has diverse endocrine and non-endocrine functionsand is ubiquitously located in the body. Its endocrine functions relate toits role as a hypothalamic factor which stimulates the release of TSH andPRL from the adenohypophysial thyrotroph and lactotroph, respectively.The role of TRH in the regulation of thyroid function and lactationis exerted by the binding of the hormone to its pituitary receptors.Regulation of the hypothalamic release of TRH may be an important factor inthe control of its bioavailability. Indeed, indirect studies suggest thatTRH plays an important role in TSH secretion during altered thyroid status, the low T3 syndrome, and acute cold exposure. Moreover, PRL secretion seemspartly dependent on hypothalamic TRH and, therefore, TRH is also considereda PRL-releasing factor. In the litterature, however, only sparse data areavailable on in vivo and in vitro release of hypothalamic TRH in conditionsassociated with altered plasma levels of TSH and/or PRL. Moreover, thesefew studies are not reconciable and the exact role of TRH in the regulationof thyroid function and lactation is far from clear.Therefore, the scope of this thesis was tohypothalamic secretion of TRH is regulated with regard toinvestigate howthyroid functionand lactation. Firstly, different neuroendocrine techniques were validatedto measure hypothalamic release of TRH (Chapter II). Secondly, theregulation of the secretion of TRH was investigated in conditionsassociated with altered plasma levels of TSH (Chapter III) and PRL (ChapterIV)." @default.
- W189819871 created "2016-06-24" @default.
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- W189819871 date "1990-05-16" @default.
- W189819871 modified "2023-09-26" @default.
- W189819871 title "Regulation of the hypothalamic release of thyrotropin-releasing hormone (TRH)" @default.
- W189819871 hasPublicationYear "1990" @default.
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