FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1900175367> ?p ?o ?g. }

• W1900175367 endingPage "646" @default.
• W1900175367 startingPage "637" @default.
• W1900175367 abstract "Cysteinyl leukotrienes (LT) are mediators involved in inflammatory and allergic disorders LTC4 synthase catalyzes the first committed step in the synthesis of these inflammatory mediators, and its cellular distribution appears to be unique.A human genomic library was screened by polymerase chain reaction (PCR) with primers that were designed based on the reported cDNA sequence for the LTC4 synthase gene. The gene was identified in one clone by Southern blotting of restriction enzyme digests, subcloning of fragments containing regions of interest, and DNA sequencing of these subclones. The transcription initiation site was determined by primer extension analysis. Chromosome location was determined by fluorescent in situ hybridization and screening of somatic cell hybrids by PCR.The LTC4 synthase gene is approximately 2.5 kb in length, consisting of five exons (136, 100, 71, 82, and 257 bp, respectively) and four introns (1,447, 102, 84, and 230 bp, respectively). Transcription initiation occurs at a single site 78 bp upstream of the coding region. The 5'-flanking region contains neither a TATA nor a CAAT box. The first 1 kb of the 5'-flanking region, however, contains putative DNA binding motifs for SP-1, AP-1, AP-2, ets factors, and CREB/ATF. A STAT binding motif is present in the first intron. The LTC4 synthase gene is located in the distal region of the long arm of chromosome 5 in 5q35.The LTC4 synthase gene does not contain elements of a typical regulated gene and may therefore contain novel regulatory elements. This gene is also located in a region on chromosome 5 that appears to play a role in allergic and inflammatory disorders, such as asthma." @default.
• W1900175367 created "2016-06-24" @default.
• W1900175367 creator A5031264902 @default.
• W1900175367 creator A5033995837 @default.
• W1900175367 creator A5040654915 @default.
• W1900175367 creator A5059816208 @default.
• W1900175367 date "1996-09-01" @default.
• W1900175367 modified "2023-10-13" @default.
• W1900175367 title "Molecular Cloning of the Human Leukotriene C4 Synthase Gene and Assignment to Chromosome 5q35" @default.
• W1900175367 cites W1487526159 @default.
• W1900175367 cites W1489769246 @default.
• W1900175367 cites W1498232017 @default.
• W1900175367 cites W1534221767 @default.
• W1900175367 cites W1535097987 @default.
• W1900175367 cites W1600740368 @default.
• W1900175367 cites W1655007348 @default.
• W1900175367 cites W1965032457 @default.
• W1900175367 cites W1970007908 @default.
• W1900175367 cites W1973352042 @default.
• W1900175367 cites W1980832959 @default.
• W1900175367 cites W1982571691 @default.
• W1900175367 cites W1994418256 @default.
• W1900175367 cites W2004351423 @default.
• W1900175367 cites W2007082033 @default.
• W1900175367 cites W2008778325 @default.
• W1900175367 cites W2014768234 @default.
• W1900175367 cites W2040062751 @default.
• W1900175367 cites W2063944231 @default.
• W1900175367 cites W2077251970 @default.
• W1900175367 cites W2078805812 @default.
• W1900175367 cites W2094472942 @default.
• W1900175367 cites W2120356456 @default.
• W1900175367 cites W2123773797 @default.
• W1900175367 cites W2127310510 @default.
• W1900175367 cites W2140411489 @default.
• W1900175367 cites W2410103733 @default.
• W1900175367 cites W243303283 @default.
• W1900175367 doi "https://doi.org/10.1007/bf03401647" @default.
• W1900175367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230200" @default.
• W1900175367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8898379" @default.
• W1900175367 hasPublicationYear "1996" @default.
• W1900175367 type Work @default.
• W1900175367 sameAs 1900175367 @default.
• W1900175367 citedByCount "42" @default.
• W1900175367 countsByYear W19001753672013 @default.
• W1900175367 countsByYear W19001753672014 @default.
• W1900175367 crossrefType "journal-article" @default.
• W1900175367 hasAuthorship W1900175367A5031264902 @default.
• W1900175367 hasAuthorship W1900175367A5033995837 @default.
• W1900175367 hasAuthorship W1900175367A5040654915 @default.
• W1900175367 hasAuthorship W1900175367A5059816208 @default.
• W1900175367 hasBestOaLocation W19001753671 @default.
• W1900175367 hasConcept C101762097 @default.
• W1900175367 hasConcept C104317684 @default.
• W1900175367 hasConcept C112243037 @default.
• W1900175367 hasConcept C150194340 @default.
• W1900175367 hasConcept C153911025 @default.
• W1900175367 hasConcept C163005120 @default.
• W1900175367 hasConcept C186493320 @default.
• W1900175367 hasConcept C194857396 @default.
• W1900175367 hasConcept C203014093 @default.
• W1900175367 hasConcept C22744801 @default.
• W1900175367 hasConcept C2776042228 @default.
• W1900175367 hasConcept C2776452501 @default.
• W1900175367 hasConcept C2779543280 @default.
• W1900175367 hasConcept C36823959 @default.
• W1900175367 hasConcept C54355233 @default.
• W1900175367 hasConcept C65888428 @default.
• W1900175367 hasConcept C67705224 @default.
• W1900175367 hasConcept C86803240 @default.
• W1900175367 hasConcept C94671646 @default.
• W1900175367 hasConceptScore W1900175367C101762097 @default.
• W1900175367 hasConceptScore W1900175367C104317684 @default.
• W1900175367 hasConceptScore W1900175367C112243037 @default.
• W1900175367 hasConceptScore W1900175367C150194340 @default.
• W1900175367 hasConceptScore W1900175367C153911025 @default.
• W1900175367 hasConceptScore W1900175367C163005120 @default.
• W1900175367 hasConceptScore W1900175367C186493320 @default.
• W1900175367 hasConceptScore W1900175367C194857396 @default.
• W1900175367 hasConceptScore W1900175367C203014093 @default.
• W1900175367 hasConceptScore W1900175367C22744801 @default.
• W1900175367 hasConceptScore W1900175367C2776042228 @default.
• W1900175367 hasConceptScore W1900175367C2776452501 @default.
• W1900175367 hasConceptScore W1900175367C2779543280 @default.
• W1900175367 hasConceptScore W1900175367C36823959 @default.
• W1900175367 hasConceptScore W1900175367C54355233 @default.
• W1900175367 hasConceptScore W1900175367C65888428 @default.
• W1900175367 hasConceptScore W1900175367C67705224 @default.
• W1900175367 hasConceptScore W1900175367C86803240 @default.
• W1900175367 hasConceptScore W1900175367C94671646 @default.
• W1900175367 hasIssue "5" @default.
• W1900175367 hasLocation W19001753671 @default.
• W1900175367 hasLocation W19001753672 @default.
• W1900175367 hasLocation W19001753673 @default.
• W1900175367 hasOpenAccess W1900175367 @default.
• W1900175367 hasPrimaryLocation W19001753671 @default.
• W1900175367 hasRelatedWork W1963837151 @default.
• W1900175367 hasRelatedWork W1971836358 @default.

• next