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- W1908015619 abstract "Aims: Cell cycle regulation in cancer is tightly linked to proliferation, metastasis, and response to chemotherapy and thus an important factor for patients' prognosis. The relevance of function and expression of central cell cycle regulators in NSCLC has been discussed with controversial and non-conclusive results. In order to shed more light on the prognostic and predictive value of cell cycle regulation in NSCLC, we evaluated expression of key regulators and correlated the data with clinico-pathologic characteristics.Methods: Expression of CDK4, cyclin D1 and p16 were analysed immunhistochemically in 1082 completely resected NSCLC by means of tissue microarrays. The data were correlated with clinico-pathologic data including patients' surival with respect to adjuvant therapy.Results In general, high expression of all cell cycle regulators was associated with better clinical outcome in a slightly variable way, depending on protein and prognostic parameters investigated. Interestingly, after stratification for therapy, the positive association of protein overexpression with survival was only seen in adenocarcinomas without adjuvant radio- and chemotherapy. In tumors with adjuvant irradiation and/or chemotherapy, the association was switched in the opposite direction.Conclusions: The expression of CDK4, cyclin D1 and p16 in NSCLC has prognostic impact depending on adjuvant therapy. As an overexpression of all three proteins was associated with improved clinical outcome in completely resected pulmonary adenocarcinomas without adjuvant therapy, these markers could be used to predict the clinical outcome of patients without adjuvant radio- and chemotherapy." @default.
- W1908015619 created "2016-06-24" @default.
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- W1908015619 date "2012-09-01" @default.
- W1908015619 modified "2023-09-26" @default.
- W1908015619 title "The expression of central cell cycle regulators in non-small cell lung cancer has therapy-dependent prognostic impact" @default.
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