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• W1915170010 startingPage "935" @default.
• W1915170010 abstract "Abstract Rheumatoid arthritis (RA) and rat models of RA exhibit symmetrical mirror‐image spread. Many studies have sought to understand the underlying mechanisms and have reported contralateral effects that are manifested in many different forms. It is now well accepted that neurogenic mechanisms contribute to the symmetrical spread of inflammation. However, very few investigators have directly assessed changes in contralateral nerve function and there is a paucity of data. In the present study our aim was to investigate whether there are changes, in particular in the nervous system but also in the vascular system contralateral to an inflamed rat knee joint, that might precede overt inflammation and symmetrical spread. Three to five days following Complete Freund's Adjuvant (CFA) injection we found spontaneous antidromic (away from the CNS) activity in the homologous sensory nerve contralateral to the inflamed joint. Antidromic activity of this nature is known to result in the peripheral release of pro‐inflammatory and vasoactive neuropeptides. Importantly, this activity was modulated by systemic analgesic treatment. Furthermore, levels of Evans blue dye extravasation were significantly increased in the joint contralateral to inflammation, indicating altered vascular function. These data suggest that contralateral increases in sensory neural activity and vascular function may account for the symmetrical spread of RA, and that early analgesic treatment may prevent or delay the spread of this debilitating disease." @default.
• W1915170010 created "2016-06-24" @default.
• W1915170010 creator A5008340259 @default.
• W1915170010 creator A5039078540 @default.
• W1915170010 creator A5091253171 @default.
• W1915170010 date "2007-08-01" @default.
• W1915170010 modified "2023-10-10" @default.
• W1915170010 title "Sensory nerves have altered function contralateral to a monoarthritis and may contribute to the symmetrical spread of inflammation" @default.
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• W1915170010 cites W156060791 @default.
• W1915170010 cites W1965765982 @default.
• W1915170010 cites W1972421997 @default.
• W1915170010 cites W1974198080 @default.
• W1915170010 cites W1993881834 @default.
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• W1915170010 cites W2001601737 @default.
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• W1915170010 doi "https://doi.org/10.1111/j.1460-9568.2007.05737.x" @default.
• W1915170010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2121144" @default.
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• W1915170010 hasPublicationYear "2007" @default.
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