FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1925855729> ?p ?o ?g. }

• W1925855729 endingPage "258" @default.
• W1925855729 startingPage "254" @default.
• W1925855729 abstract "Marek's disease virus (MDV) is an oncogenic alphaherpesvirus and the causative agent of Marek's disease (MD), characterized by immunosuppression, paralysis, nerve enlargement and induction of T-cell lymphomas in chickens. Despite widespread usage of vaccines since the 1970s to control MD, more virulent field strains of MDV have emerged that overcome vaccinal protection, necessitating the development of new and more protective MD vaccines. The ∆Meq virus, a recombinant Md5 strain MDV lacking the viral oncogene Meq, is one candidate MD vaccine with great potential but unfortunately it also causes bursal–thymic atrophy (BTA) in maternal antibody negative chickens, raising concerns that impede commercial use as a vaccine. Previously, we identified a point mutation within UL5 that reduced in vivo replication in attenuated viruses. We proposed that introduction of the UL5 point mutation into the ∆Meq virus would reduce in vivo replication and eliminate BTA yet potentially retain high protective abilities. In birds, the ∆Meq+UL5 recombinant MDV had reduced replication compared to the original ∆Meq virus, while weights of lymphoid organs indicated that ∆Meq+UL5 did not induce BTA, supporting the hypothesis that reduction of in vivo replication would also abolish BTA. Vaccine trials of the ∆Meq+UL5 virus compared to other ∆Meq-based viruses and commercial vaccines show that, while the ∆Meq+UL5 does provide vaccinal protection, this protection was also reduced compared to the original ∆Meq virus. Therefore, it appears that a very delicate balance is required between levels of replication able to induce high vaccinal protection, yet not so high as to induce BTA." @default.
• W1925855729 created "2016-06-24" @default.
• W1925855729 creator A5023558807 @default.
• W1925855729 creator A5064384439 @default.
• W1925855729 creator A5088204473 @default.
• W1925855729 date "2015-07-04" @default.
• W1925855729 modified "2023-09-24" @default.
• W1925855729 title "Addition of a UL5 helicase-primase subunit point mutation eliminates bursal–thymic atrophy of Marek's disease virus ∆Meq recombinant virus but reduces vaccinal protection" @default.
• W1925855729 cites W1777044217 @default.
• W1925855729 cites W1967837085 @default.
• W1925855729 cites W1976776921 @default.
• W1925855729 cites W1985555713 @default.
• W1925855729 cites W1988260036 @default.
• W1925855729 cites W2010233836 @default.
• W1925855729 cites W2031841357 @default.
• W1925855729 cites W2035073629 @default.
• W1925855729 cites W2038994139 @default.
• W1925855729 cites W2039551089 @default.
• W1925855729 cites W2055983573 @default.
• W1925855729 cites W2061800646 @default.
• W1925855729 cites W2070429838 @default.
• W1925855729 cites W2076920505 @default.
• W1925855729 cites W2110059232 @default.
• W1925855729 cites W2140215721 @default.
• W1925855729 cites W2175675229 @default.
• W1925855729 cites W2320365439 @default.
• W1925855729 cites W2332151453 @default.
• W1925855729 cites W40133871 @default.
• W1925855729 cites W8305462 @default.
• W1925855729 doi "https://doi.org/10.1080/03079457.2015.1041366" @default.
• W1925855729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25968878" @default.
• W1925855729 hasPublicationYear "2015" @default.
• W1925855729 type Work @default.
• W1925855729 sameAs 1925855729 @default.
• W1925855729 citedByCount "5" @default.
• W1925855729 countsByYear W19258557292015 @default.
• W1925855729 countsByYear W19258557292019 @default.
• W1925855729 countsByYear W19258557292020 @default.
• W1925855729 countsByYear W19258557292021 @default.
• W1925855729 countsByYear W19258557292022 @default.
• W1925855729 crossrefType "journal-article" @default.
• W1925855729 hasAuthorship W1925855729A5023558807 @default.
• W1925855729 hasAuthorship W1925855729A5064384439 @default.
• W1925855729 hasAuthorship W1925855729A5088204473 @default.
• W1925855729 hasBestOaLocation W19258557291 @default.
• W1925855729 hasConcept C140704245 @default.
• W1925855729 hasConcept C159047783 @default.
• W1925855729 hasConcept C2522874641 @default.
• W1925855729 hasConcept C2777852405 @default.
• W1925855729 hasConcept C86803240 @default.
• W1925855729 hasConceptScore W1925855729C140704245 @default.
• W1925855729 hasConceptScore W1925855729C159047783 @default.
• W1925855729 hasConceptScore W1925855729C2522874641 @default.
• W1925855729 hasConceptScore W1925855729C2777852405 @default.
• W1925855729 hasConceptScore W1925855729C86803240 @default.
• W1925855729 hasIssue "4" @default.
• W1925855729 hasLocation W19258557291 @default.
• W1925855729 hasLocation W19258557292 @default.
• W1925855729 hasOpenAccess W1925855729 @default.
• W1925855729 hasPrimaryLocation W19258557291 @default.
• W1925855729 hasRelatedWork W1516164909 @default.
• W1925855729 hasRelatedWork W1996860867 @default.
• W1925855729 hasRelatedWork W2089393005 @default.
• W1925855729 hasRelatedWork W2098798974 @default.
• W1925855729 hasRelatedWork W2366557760 @default.
• W1925855729 hasRelatedWork W2408900517 @default.
• W1925855729 hasRelatedWork W2421135693 @default.
• W1925855729 hasRelatedWork W2614099983 @default.
• W1925855729 hasRelatedWork W4385933241 @default.
• W1925855729 hasRelatedWork W647074146 @default.
• W1925855729 hasVolume "44" @default.
• W1925855729 isParatext "false" @default.
• W1925855729 isRetracted "false" @default.
• W1925855729 magId "1925855729" @default.
• W1925855729 workType "article" @default.