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- W1938378466 abstract "Aspirin is widely prescribed and confers considerable benefit to patients by reducing cardiovascular and cerebrovascular morbidity and mortality. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are effective analgesics, antipyretics and reduce the inflammatory component in conditions such as rheumatoid arthritis. However, both agents are associated with an increased risk of gastrointestinal symptoms and the potentially serious consequences of gastroduodenal ulceration, bleeding and perforation. The introduction of highly selective cyclo‐oxygenase (COX)‐2 inhibitors or the coprescription gastroprotective agents with nonselective NSAIDs have offered strategies to reduce the incidence of such events. This review article analyzes the quantitative techniques that can be employed by clinical pharmacologists and the clinical studies performed to assess NSAID damage in the gastrointestinal tract." @default.
- W1938378466 created "2016-06-24" @default.
- W1938378466 creator A5018445266 @default.
- W1938378466 creator A5091641892 @default.
- W1938378466 date "2003-07-31" @default.
- W1938378466 modified "2023-10-17" @default.
- W1938378466 title "Assessment of non-steroidal anti-inflammatory drug (NSAID) damage in the human gastrointestinal tract" @default.
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- W1938378466 doi "https://doi.org/10.1046/j.1365-2125.2003.01934.x" @default.
- W1938378466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1884286" @default.
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