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• W1946221762 endingPage "69" @default.
• W1946221762 startingPage "60" @default.
• W1946221762 abstract "Chronic periodontitis has a polymicrobial biofilm aetiology. Polymicrobial biofilms are complex, dynamic microbial communities formed by two or more bacterial species that are important for the persistence and proliferation of participating microbes in the environment. Interspecies adherence, which often involves bacterial surface-associated molecules, and communications are essential in the spatial and temporal development of a polymicrobial biofilm, which in turn is necessary for the overall fitness of a well-organized multispecies biofilm community. In the oral cavity, interactions between key oral bacterial species, including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are essential for the progression of chronic periodontitis. In vivo, P. gingivalis and T. denticola are frequently found to co-exist in deep periodontal pockets and have been co-localized to the superficial layers of subgingival plaque as microcolony blooms adjacent to the pocket epithelium, suggesting possible interbacterial interactions that contribute towards disease. The motility and chemotactic ability of T. denticola, although not considered as classic virulence factors, are likely to be important in the synergistic biofilm formation with P. gingivalis. In vitro, P. gingivalis and T. denticola display a symbiotic relationship in nutrient utilization and growth promotion. Together these data suggest there is an intimate relationship between these two species that has evolved to enhance their survival and virulence." @default.
• W1946221762 created "2016-06-24" @default.
• W1946221762 creator A5031377587 @default.
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• W1946221762 creator A5045261132 @default.
• W1946221762 creator A5048673467 @default.
• W1946221762 creator A5059998268 @default.
• W1946221762 date "2016-05-01" @default.
• W1946221762 modified "2023-09-26" @default.
• W1946221762 title "Bacterial interactions in pathogenic subgingival plaque" @default.
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