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• W1965765629 endingPage "435" @default.
• W1965765629 startingPage "429" @default.
• W1965765629 abstract "The crystal structures of aprotinin and its complex with sucrose octasulfate (SOS), a polysulfated heparin analog, were determined at 1.7-2.6A resolutions. Aprotinin is monomeric in solution, which associates into a decamer at high salt concentrations. Sulfate ions serve to neutralize the basic amino acid residues of aprotinin to stabilize the decameric aprotinin. Whereas SOS interacts with heparin binding proteins at 1:1 molar ratio, SOS was surprisingly found to induce strong agglutination of aprotinins. Five molecules of aprotinin interact with one molecule of the sulfated sugar, which is stabilized by electrostatic interactions between the positively charged residues of aprotinin and sulfate groups of SOS. The multiple binding modes of SOS with five individual aprotinin molecules may represent the diverse patterns of potential heparin binding to aprotinin, reflecting the interactions of densely packed protein molecules along the heparin polymer." @default.
• W1965765629 created "2016-06-24" @default.
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• W1965765629 date "2010-07-01" @default.
• W1965765629 modified "2023-10-14" @default.
• W1965765629 title "Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding" @default.
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• W1965765629 doi "https://doi.org/10.1016/j.bbrc.2010.05.113" @default.
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