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- W1965868312 abstract "Improving vaccine immunogenicity remains a major challenge in the fight against developing country diseases like malaria and AIDS. We describe a novel strategy to identify new DNA vaccine adjuvants. We have screened components of the Toll-like receptor signalling pathways for their ability to activate pro-inflammatory target genes in transient transfection assays and assessed in vivo adjuvant activity by expressing the activators from the DNA backbone of vaccines. We find that a robust increase in the immune response necessitates co-expression of two activators. Accordingly, the combination of tak1 and tram elicits synergistic reporter activation in transient transfection assays. In a mouse model this combination, but not the individual molecules, induced approximately twofold increases in CD8+ T-cell immune responses. These results indicate that optimal immunogenicity may require activation of distinct innate immune signalling pathways. Thus this strategy offers a novel route to the discovery of a new generation of adjuvants." @default.
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- W1965868312 date "2009-09-01" @default.
- W1965868312 modified "2023-10-18" @default.
- W1965868312 title "Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines" @default.
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- W1965868312 doi "https://doi.org/10.1016/j.vaccine.2009.07.025" @default.
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