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- W1965933247 abstract "Significance Hybrid sterility contributes to speciation by restricting gene flow between related taxa. Although four hybrid sterility genes have been identified in Drosophila and mouse so far, the underlying molecular mechanisms are largely unknown. We describe extensive asynapsis of chromosomes in male and female meiosis of F1 hybrids between two closely related mouse subspecies. Using the intersubspecific chromosome-substitution strains, we demonstrate that the heterospecific pairing of homologous chromosomes is a preexisting condition of asynapsis and may represent a universal mechanism of pachytene arrest in interspecific hybrids. Sex-specific manifestation of asynapsis can explain the mechanism of Haldane’s rule." @default.
- W1965933247 created "2016-06-24" @default.
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- W1965933247 date "2013-01-17" @default.
- W1965933247 modified "2023-10-17" @default.
- W1965933247 title "Mechanistic basis of infertility of mouse intersubspecific hybrids" @default.
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- W1965933247 doi "https://doi.org/10.1073/pnas.1219126110" @default.
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