FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965971290> ?p ?o ?g. }

• W1965971290 endingPage "773" @default.
• W1965971290 startingPage "766" @default.
• W1965971290 abstract "Renal dysfunction is closely associated with endothelial damage leading to cardiovascular disease. However, the extent to which endothelial damage induced by uremia is modulated by aging is poorly known. Aging can render endothelial cells more susceptible to apoptosis through an oxidative stress-dependent pathway. We examined whether senescence-associated to oxidative stress determines the injury induced by the uremia in endothelial cells. Human umbilical vein endothelial cells (HUVEC) was incubated with human uremic serum and, in the animal model, endothelial cells were obtained from aortas of uremic and no uremic rats. Vitamin C was used to prevent oxidative stress. Senescence, assessed by telomere length and enzyme-betagalactosidase (β-gal), reactive oxygen species (ROS), mitochondrial depolarization (JC-1 probe), caspase 3, and apoptosis were determined by flow cytometry. NF-κB activity was determined by Western blot. Uremic serum increased ROS and NF-κB in young and aging HUVEC. However only in aging cells, uremic serum induced apoptosis (vs young HUVEC, p < 0.01). The endothelial damage induced by uremia seems to be related with the increased oxidative stress, since in both HUVEC and in the experimental model of renal disease in rats, vitamin C prevents endothelial apoptosis. However, vitamin C did not decrease the oxidative stress associated to senescence. These results showed that as compared with young cells, senescent cells have high sensitivity to damage associated to the oxidative stress induced by the uremia. Consequently, protecting senescent endothelial cells from increased oxidative stress might be an effective therapeutic approach in the treatment of vascular disorders in chronic kidney diseases." @default.
• W1965971290 created "2016-06-24" @default.
• W1965971290 creator A5002461480 @default.
• W1965971290 creator A5017209584 @default.
• W1965971290 creator A5018039604 @default.
• W1965971290 creator A5019936644 @default.
• W1965971290 creator A5029079538 @default.
• W1965971290 creator A5046218180 @default.
• W1965971290 creator A5076472196 @default.
• W1965971290 creator A5088437735 @default.
• W1965971290 date "2013-08-01" @default.
• W1965971290 modified "2023-10-16" @default.
• W1965971290 title "Cellular senescence determines endothelial cell damage induced by uremia" @default.
• W1965971290 cites W1857010474 @default.
• W1965971290 cites W1963812200 @default.
• W1965971290 cites W1976588622 @default.
• W1965971290 cites W1979504051 @default.
• W1965971290 cites W1997093408 @default.
• W1965971290 cites W2004230365 @default.
• W1965971290 cites W2010345740 @default.
• W1965971290 cites W2014912907 @default.
• W1965971290 cites W2015555366 @default.
• W1965971290 cites W2027974713 @default.
• W1965971290 cites W2031167756 @default.
• W1965971290 cites W2037732138 @default.
• W1965971290 cites W2038924840 @default.
• W1965971290 cites W2061755142 @default.
• W1965971290 cites W2066915043 @default.
• W1965971290 cites W2075479208 @default.
• W1965971290 cites W2110754582 @default.
• W1965971290 cites W2115478977 @default.
• W1965971290 cites W2118265549 @default.
• W1965971290 cites W2122252172 @default.
• W1965971290 cites W2124098526 @default.
• W1965971290 cites W2134052088 @default.
• W1965971290 cites W2137496003 @default.
• W1965971290 cites W2145073188 @default.
• W1965971290 cites W2148454175 @default.
• W1965971290 cites W2169123846 @default.
• W1965971290 doi "https://doi.org/10.1016/j.exger.2013.04.004" @default.
• W1965971290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23624226" @default.
• W1965971290 hasPublicationYear "2013" @default.
• W1965971290 type Work @default.
• W1965971290 sameAs 1965971290 @default.
• W1965971290 citedByCount "41" @default.
• W1965971290 countsByYear W19659712902013 @default.
• W1965971290 countsByYear W19659712902014 @default.
• W1965971290 countsByYear W19659712902015 @default.
• W1965971290 countsByYear W19659712902016 @default.
• W1965971290 countsByYear W19659712902017 @default.
• W1965971290 countsByYear W19659712902018 @default.
• W1965971290 countsByYear W19659712902019 @default.
• W1965971290 countsByYear W19659712902020 @default.
• W1965971290 countsByYear W19659712902021 @default.
• W1965971290 countsByYear W19659712902022 @default.
• W1965971290 countsByYear W19659712902023 @default.
• W1965971290 crossrefType "journal-article" @default.
• W1965971290 hasAuthorship W1965971290A5002461480 @default.
• W1965971290 hasAuthorship W1965971290A5017209584 @default.
• W1965971290 hasAuthorship W1965971290A5018039604 @default.
• W1965971290 hasAuthorship W1965971290A5019936644 @default.
• W1965971290 hasAuthorship W1965971290A5029079538 @default.
• W1965971290 hasAuthorship W1965971290A5046218180 @default.
• W1965971290 hasAuthorship W1965971290A5076472196 @default.
• W1965971290 hasAuthorship W1965971290A5088437735 @default.
• W1965971290 hasConcept C123012128 @default.
• W1965971290 hasConcept C126322002 @default.
• W1965971290 hasConcept C134018914 @default.
• W1965971290 hasConcept C185592680 @default.
• W1965971290 hasConcept C190283241 @default.
• W1965971290 hasConcept C202751555 @default.
• W1965971290 hasConcept C2776151105 @default.
• W1965971290 hasConcept C2776635150 @default.
• W1965971290 hasConcept C2777411675 @default.
• W1965971290 hasConcept C2780972559 @default.
• W1965971290 hasConcept C31573885 @default.
• W1965971290 hasConcept C48349386 @default.
• W1965971290 hasConcept C522857546 @default.
• W1965971290 hasConcept C55493867 @default.
• W1965971290 hasConcept C71924100 @default.
• W1965971290 hasConcept C86803240 @default.
• W1965971290 hasConcept C95444343 @default.
• W1965971290 hasConceptScore W1965971290C123012128 @default.
• W1965971290 hasConceptScore W1965971290C126322002 @default.
• W1965971290 hasConceptScore W1965971290C134018914 @default.
• W1965971290 hasConceptScore W1965971290C185592680 @default.
• W1965971290 hasConceptScore W1965971290C190283241 @default.
• W1965971290 hasConceptScore W1965971290C202751555 @default.
• W1965971290 hasConceptScore W1965971290C2776151105 @default.
• W1965971290 hasConceptScore W1965971290C2776635150 @default.
• W1965971290 hasConceptScore W1965971290C2777411675 @default.
• W1965971290 hasConceptScore W1965971290C2780972559 @default.
• W1965971290 hasConceptScore W1965971290C31573885 @default.
• W1965971290 hasConceptScore W1965971290C48349386 @default.
• W1965971290 hasConceptScore W1965971290C522857546 @default.
• W1965971290 hasConceptScore W1965971290C55493867 @default.
• W1965971290 hasConceptScore W1965971290C71924100 @default.
• W1965971290 hasConceptScore W1965971290C86803240 @default.

• next