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- W1966390143 abstract "Prostaglandin E1 has been clinically used in a variety of vascular occlusive diseases. We investigated the in vitro effect of prostaglandin E1 on the synthesis of tumor necrosis factor-alpha, interleukin-1, interleukin-6, interleukin-10 and transforming growth factor beta by human peripheral blood mononuclear cells stimulated with lipopolysaccharides. Prostaglandin E1 significantly suppressed both the mRNA expression and the production of tumor necrosis factor-alpha and interleukin-10 by lipopolysaccharides-stimulated peripheral blood mononuclear cells in a dose-dependent manner (1 x 10(-6)-1 x 10(-8) M). Since tumor necrosis factor-alpha is a potent proinflammatory cytokine involved in certain inflammatory diseases, our findings suggest the possibility to expand the clinical application of prostaglandin E1." @default.
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- W1966390143 date "1998-02-01" @default.
- W1966390143 modified "2023-10-18" @default.
- W1966390143 title "Prostaglandin E1 suppresses tumor necrosis factor-α and interleukin-10 production by lipopolysaccharides-stimulated mononuclear cells" @default.
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- W1966390143 doi "https://doi.org/10.1016/s0014-2999(97)01575-6" @default.
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