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- W1966728557 abstract "The radiosensitivity of two human cell lines, Ma 11 and Be 11, each arising from a human melanoma, was studied. The tumors were transplanted into nude mice and irradiated in situ, and the colony-forming ability was tested in vitro. The D/sub 0/ values obtained under these conditions were 4.22 and 5.85 Gy for Ma 11 and Be 11, respectively. The surviving fraction of irradiated cells increased when tumor excision was delayed for 6 hr. The Be 11 line contained 40% hypoxic cells; the corresponding figure for Ma 11 was 62%. These figures like that previously determined for another malanoma (85%), are among the highest reported in the literature. For solid tumors, only 10% of tumors have a hypoxic cell fraction greater than 40%; this high fraction may partially explain the radioresistance of human melanomas." @default.
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- W1966728557 date "1981-10-01" @default.
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- W1966728557 title "Hypoxic Fraction and Repair of Potentially Lethal Radiation Damage in Two Human Melanomas Transplanted into Nude Mice" @default.
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- W1966728557 doi "https://doi.org/10.2307/3575751" @default.
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