FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967367628> ?p ?o ?g. }

• W1967367628 endingPage "43" @default.
• W1967367628 startingPage "36" @default.
• W1967367628 abstract "Broiler chickens (Gallus gallus) genetically selected for rapid growth are inherently predisposed to heart failure. In order to understand the biochemical mechanisms associated with the deterioration of heart function and development of congestive heart failure (CHF) in fast-growing chickens, this study examined several factors critical for myocardial energy metabolism. Measured variables included cardiac energy substrates [creatine phosphate (CrP), adenosine triphosphate (ATP), l-carnitine], activity of selected cytosolic enzymes [creatine kinase (CK; EC 2.7.3.2), lactate dehydrogenase (LDH; EC 1.1.1.27)] and mitochondrial enzymes [pyruvate dehydrogenase (PDH; EC 1.2.4.1), α-ketoglutarate dehydrogenase (α-KGDH; EC 1.2.4.2)]. The CK activities were higher in fast-growing and CHF broilers as compared to slow-growing broilers (p < 0.05). Cardiac LDH and α-KGDH activities were not changed (p > 0.05), whereas PDH activity was highest (p < 0.05) in broilers with CHF. Deterioration of heart function is correlated with lowered cardiac ATP, CrP, and l-carnitine levels (all p < 0.05). Depletion of high energy phosphate substrates, ATP and CrP, is evident in fast-growing chickens and those that developed CHF. Increased activity of CK suggests that cardiac energy management in fast-growing broilers and those with CHF largely depends on contribution of this pathway to regeneration of ATP from CrP. In this scenario, inadequate level of CrP is a direct cause of ATP insufficiency, whereas low cardiac l-carnitine, because of its role in fatty acid transport, is most likely an important factor contributing to shortage of key substrate required for synthesis of cardiac ATP. The insufficiencies in cardiac energy substrate synthesis provide metabolic basis of myocardial dysfunction in chickens predisposed to heart failure." @default.
• W1967367628 created "2016-06-24" @default.
• W1967367628 creator A5037866707 @default.
• W1967367628 creator A5041805010 @default.
• W1967367628 creator A5054628551 @default.
• W1967367628 creator A5062398753 @default.
• W1967367628 creator A5066828201 @default.
• W1967367628 creator A5077695507 @default.
• W1967367628 date "2008-01-01" @default.
• W1967367628 modified "2023-09-27" @default.
• W1967367628 title "Biochemical factors limiting myocardial energy in a chicken genotype selected for rapid growth" @default.
• W1967367628 cites W1492682176 @default.
• W1967367628 cites W1569055531 @default.
• W1967367628 cites W1968499272 @default.
• W1967367628 cites W1969216295 @default.
• W1967367628 cites W1973628359 @default.
• W1967367628 cites W1976083704 @default.
• W1967367628 cites W1981890133 @default.
• W1967367628 cites W1987632681 @default.
• W1967367628 cites W1999766077 @default.
• W1967367628 cites W2005399678 @default.
• W1967367628 cites W2007809577 @default.
• W1967367628 cites W2020946426 @default.
• W1967367628 cites W2023869354 @default.
• W1967367628 cites W2027979676 @default.
• W1967367628 cites W2029887072 @default.
• W1967367628 cites W2031910796 @default.
• W1967367628 cites W2037361270 @default.
• W1967367628 cites W2039872006 @default.
• W1967367628 cites W2040972509 @default.
• W1967367628 cites W2044744891 @default.
• W1967367628 cites W2050626175 @default.
• W1967367628 cites W2066269008 @default.
• W1967367628 cites W2071518542 @default.
• W1967367628 cites W2079997990 @default.
• W1967367628 cites W2085804980 @default.
• W1967367628 cites W2091193148 @default.
• W1967367628 cites W2138815583 @default.
• W1967367628 cites W2141122893 @default.
• W1967367628 cites W2152979788 @default.
• W1967367628 cites W2153819921 @default.
• W1967367628 cites W2169058037 @default.
• W1967367628 cites W2171577891 @default.
• W1967367628 cites W2178313645 @default.
• W1967367628 cites W2178848420 @default.
• W1967367628 cites W2316183125 @default.
• W1967367628 cites W2317167001 @default.
• W1967367628 cites W2319480592 @default.
• W1967367628 cites W2333456957 @default.
• W1967367628 doi "https://doi.org/10.1016/j.cbpa.2007.10.001" @default.
• W1967367628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17988909" @default.
• W1967367628 hasPublicationYear "2008" @default.
• W1967367628 type Work @default.
• W1967367628 sameAs 1967367628 @default.
• W1967367628 citedByCount "24" @default.
• W1967367628 countsByYear W19673676282012 @default.
• W1967367628 countsByYear W19673676282013 @default.
• W1967367628 countsByYear W19673676282014 @default.
• W1967367628 countsByYear W19673676282015 @default.
• W1967367628 countsByYear W19673676282017 @default.
• W1967367628 countsByYear W19673676282018 @default.
• W1967367628 countsByYear W19673676282019 @default.
• W1967367628 countsByYear W19673676282020 @default.
• W1967367628 countsByYear W19673676282021 @default.
• W1967367628 countsByYear W19673676282023 @default.
• W1967367628 crossrefType "journal-article" @default.
• W1967367628 hasAuthorship W1967367628A5037866707 @default.
• W1967367628 hasAuthorship W1967367628A5041805010 @default.
• W1967367628 hasAuthorship W1967367628A5054628551 @default.
• W1967367628 hasAuthorship W1967367628A5062398753 @default.
• W1967367628 hasAuthorship W1967367628A5066828201 @default.
• W1967367628 hasAuthorship W1967367628A5077695507 @default.
• W1967367628 hasConcept C100206155 @default.
• W1967367628 hasConcept C111133373 @default.
• W1967367628 hasConcept C111566952 @default.
• W1967367628 hasConcept C126322002 @default.
• W1967367628 hasConcept C134018914 @default.
• W1967367628 hasConcept C181199279 @default.
• W1967367628 hasConcept C20251656 @default.
• W1967367628 hasConcept C2776317432 @default.
• W1967367628 hasConcept C2777318727 @default.
• W1967367628 hasConcept C2778198053 @default.
• W1967367628 hasConcept C2778435403 @default.
• W1967367628 hasConcept C2779896295 @default.
• W1967367628 hasConcept C2780289900 @default.
• W1967367628 hasConcept C2780854706 @default.
• W1967367628 hasConcept C28859421 @default.
• W1967367628 hasConcept C31903555 @default.
• W1967367628 hasConcept C36880943 @default.
• W1967367628 hasConcept C55493867 @default.
• W1967367628 hasConcept C62231903 @default.
• W1967367628 hasConcept C71924100 @default.
• W1967367628 hasConcept C86803240 @default.
• W1967367628 hasConceptScore W1967367628C100206155 @default.
• W1967367628 hasConceptScore W1967367628C111133373 @default.
• W1967367628 hasConceptScore W1967367628C111566952 @default.
• W1967367628 hasConceptScore W1967367628C126322002 @default.
• W1967367628 hasConceptScore W1967367628C134018914 @default.

• next