FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968054311> ?p ?o ?g. }

• W1968054311 abstract "HLA molecules are cell-surface glycoproteins that present peptides, derived from intracellular protein antigens, for surveillance by T lymphocytes. Secreted HLA (sHLA) technology is a powerful approach for studying these peptides, since it facilitates large-scale production of HLA-bound peptides. We compared secreted and membrane-bound forms of HLA A2 in terms of intracellular trafficking and their bound peptide repertoire (termed the immunopeptidome). We demonstrate that sHLA and membrane bound HLA (mHLA) negotiate intracellular compartments with similar maturation kinetics. Moreover, mass spectrometry revealed a substantial overlap in the immunopeptidome was observed when HLA A2-bound peptides were purified from various sources of sHLA and mHLA. By combining machine based algorithms with manual validation, we identified 1266 non-redundant peptides. Analysis of these peptides revealed a number bearing post-translational modifications, although some of these may arise spontaneously others represent modifications performed within the cell that survive antigen processing. Peptides bearing some of these modifications have not previously been described for HLA ligands, therefore, this compendium of 1266 non-redundant peptide sequences adds greatly to the existing database of HLA A2 ligands. Peptides from all sources displayed comparable HLA A2 consensus binding motifs, peptide lengths, predicted HLA A2 binding affinities and putative source antigens. We conclude that sHLA is a valid and useful technique for studying the immunopeptidome." @default.
• W1968054311 created "2016-06-24" @default.
• W1968054311 creator A5008809175 @default.
• W1968054311 creator A5019206191 @default.
• W1968054311 creator A5020015540 @default.
• W1968054311 creator A5055577385 @default.
• W1968054311 creator A5057747777 @default.
• W1968054311 creator A5079446051 @default.
• W1968054311 creator A5087347737 @default.
• W1968054311 date "2012-06-01" @default.
• W1968054311 modified "2023-09-27" @default.
• W1968054311 title "Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands" @default.
• W1968054311 cites W1508835015 @default.
• W1968054311 cites W1598930263 @default.
• W1968054311 cites W1969124154 @default.
• W1968054311 cites W1971302107 @default.
• W1968054311 cites W1973323839 @default.
• W1968054311 cites W1980048816 @default.
• W1968054311 cites W1983708531 @default.
• W1968054311 cites W1997687040 @default.
• W1968054311 cites W1998260902 @default.
• W1968054311 cites W1998406628 @default.
• W1968054311 cites W2005105337 @default.
• W1968054311 cites W2008774884 @default.
• W1968054311 cites W2020846586 @default.
• W1968054311 cites W2026970642 @default.
• W1968054311 cites W2046509071 @default.
• W1968054311 cites W2053781768 @default.
• W1968054311 cites W2056964537 @default.
• W1968054311 cites W2061234769 @default.
• W1968054311 cites W2069080357 @default.
• W1968054311 cites W2071090669 @default.
• W1968054311 cites W2074513702 @default.
• W1968054311 cites W2089345952 @default.
• W1968054311 cites W2089374733 @default.
• W1968054311 cites W2094660101 @default.
• W1968054311 cites W2115129497 @default.
• W1968054311 cites W2123434474 @default.
• W1968054311 cites W2141043558 @default.
• W1968054311 cites W2163107468 @default.
• W1968054311 cites W2165157894 @default.
• W1968054311 doi "https://doi.org/10.1016/j.molimm.2012.02.117" @default.
• W1968054311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22424782" @default.
• W1968054311 hasPublicationYear "2012" @default.
• W1968054311 type Work @default.
• W1968054311 sameAs 1968054311 @default.
• W1968054311 citedByCount "41" @default.
• W1968054311 countsByYear W19680543112013 @default.
• W1968054311 countsByYear W19680543112014 @default.
• W1968054311 countsByYear W19680543112015 @default.
• W1968054311 countsByYear W19680543112016 @default.
• W1968054311 countsByYear W19680543112017 @default.
• W1968054311 countsByYear W19680543112018 @default.
• W1968054311 countsByYear W19680543112019 @default.
• W1968054311 countsByYear W19680543112020 @default.
• W1968054311 countsByYear W19680543112021 @default.
• W1968054311 countsByYear W19680543112022 @default.
• W1968054311 countsByYear W19680543112023 @default.
• W1968054311 crossrefType "journal-article" @default.
• W1968054311 hasAuthorship W1968054311A5008809175 @default.
• W1968054311 hasAuthorship W1968054311A5019206191 @default.
• W1968054311 hasAuthorship W1968054311A5020015540 @default.
• W1968054311 hasAuthorship W1968054311A5055577385 @default.
• W1968054311 hasAuthorship W1968054311A5057747777 @default.
• W1968054311 hasAuthorship W1968054311A5079446051 @default.
• W1968054311 hasAuthorship W1968054311A5087347737 @default.
• W1968054311 hasConcept C147483822 @default.
• W1968054311 hasConcept C153911025 @default.
• W1968054311 hasConcept C185592680 @default.
• W1968054311 hasConcept C188280979 @default.
• W1968054311 hasConcept C203014093 @default.
• W1968054311 hasConcept C2775866039 @default.
• W1968054311 hasConcept C2779281246 @default.
• W1968054311 hasConcept C55493867 @default.
• W1968054311 hasConcept C70721500 @default.
• W1968054311 hasConcept C79879829 @default.
• W1968054311 hasConcept C86803240 @default.
• W1968054311 hasConceptScore W1968054311C147483822 @default.
• W1968054311 hasConceptScore W1968054311C153911025 @default.
• W1968054311 hasConceptScore W1968054311C185592680 @default.
• W1968054311 hasConceptScore W1968054311C188280979 @default.
• W1968054311 hasConceptScore W1968054311C203014093 @default.
• W1968054311 hasConceptScore W1968054311C2775866039 @default.
• W1968054311 hasConceptScore W1968054311C2779281246 @default.
• W1968054311 hasConceptScore W1968054311C55493867 @default.
• W1968054311 hasConceptScore W1968054311C70721500 @default.
• W1968054311 hasConceptScore W1968054311C79879829 @default.
• W1968054311 hasConceptScore W1968054311C86803240 @default.
• W1968054311 hasLocation W19680543111 @default.
• W1968054311 hasLocation W19680543112 @default.
• W1968054311 hasOpenAccess W1968054311 @default.
• W1968054311 hasPrimaryLocation W19680543111 @default.
• W1968054311 hasRelatedWork W103732085 @default.
• W1968054311 hasRelatedWork W144653500 @default.
• W1968054311 hasRelatedWork W1821051263 @default.
• W1968054311 hasRelatedWork W1978174636 @default.
• W1968054311 hasRelatedWork W2053502407 @default.
• W1968054311 hasRelatedWork W2156203390 @default.
• W1968054311 hasRelatedWork W2606115399 @default.
• W1968054311 hasRelatedWork W2996345839 @default.

• next