FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968954858> ?p ?o ?g. }

• W1968954858 endingPage "786" @default.
• W1968954858 startingPage "781" @default.
• W1968954858 abstract "Nodal marginal zone B-cell lymphoma (MZL) is a rare and not extensively studied entity that accounts for approximately 2% of all non-Hodgkin lymphomas. Complementarity-determining regions 2 and 3 (CDR2, CDR3) of the immunoglobulin heavy-chain variable region (VH) genes were amplified by polymerase chain reaction (PCR), cloned, and sequenced in 8 patients with nodal MZL. All showed a potentially functional VH rearrangement. The use of VH gene families was unbiased and without overrepresentation of any particular VH gene or gene family. The presence of somatic VH mutations was detected, with a deviation from the closest germ line sequence ranging from 4% to 17% in 6 of 8 patients. In 3 mutations, the replacement-to-silent mutation ratio suggested the presence of an antigen-selected process. Sequencing different subclones of the same cloned PCR products allowed the detection of intraclonal variability in 4 analyzed patients. The observed pattern of VH mutations suggested that nodal MZL, formerly deemed a malignancy of memory B cells, may arise from different subsets of marginal zone B cells—the naive B cells that express unmutated VH genes—from memory B cells showing somatic mutations without intraclonal variation, and from germinal center B cells defined by their capacity to undergo the somatic hypermutation process. Subjects: Neoplasia Topics: antigens, b-lymphocytes, genes, immunoglobulin variable region, immunoglobulins, mutation, nodal marginal zone b-cell lymphoma, polymerase chain reaction, mutation, somatic, germinal center of lymph node" @default.
• W1968954858 created "2016-06-24" @default.
• W1968954858 creator A5016803459 @default.
• W1968954858 creator A5028007261 @default.
• W1968954858 creator A5036693524 @default.
• W1968954858 creator A5049503939 @default.
• W1968954858 creator A5066518317 @default.
• W1968954858 creator A5067952728 @default.
• W1968954858 creator A5081539801 @default.
• W1968954858 creator A5082847339 @default.
• W1968954858 creator A5088261921 @default.
• W1968954858 creator A5090350899 @default.
• W1968954858 date "2001-08-01" @default.
• W1968954858 modified "2023-09-30" @default.
• W1968954858 title "Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes" @default.
• W1968954858 cites W1009164044 @default.
• W1968954858 cites W112705421 @default.
• W1968954858 cites W1243376384 @default.
• W1968954858 cites W132958028 @default.
• W1968954858 cites W1429374962 @default.
• W1968954858 cites W1488100440 @default.
• W1968954858 cites W1489752929 @default.
• W1968954858 cites W1594564120 @default.
• W1968954858 cites W1712157683 @default.
• W1968954858 cites W179775406 @default.
• W1968954858 cites W1841849842 @default.
• W1968954858 cites W1847317677 @default.
• W1968954858 cites W1975100378 @default.
• W1968954858 cites W1978876837 @default.
• W1968954858 cites W1987684443 @default.
• W1968954858 cites W1994096261 @default.
• W1968954858 cites W1998675277 @default.
• W1968954858 cites W200132913 @default.
• W1968954858 cites W2001679455 @default.
• W1968954858 cites W2006099833 @default.
• W1968954858 cites W2008954602 @default.
• W1968954858 cites W2010459522 @default.
• W1968954858 cites W2012987393 @default.
• W1968954858 cites W2020034788 @default.
• W1968954858 cites W2027505310 @default.
• W1968954858 cites W2031263707 @default.
• W1968954858 cites W2041899298 @default.
• W1968954858 cites W2056826022 @default.
• W1968954858 cites W2063171573 @default.
• W1968954858 cites W2071344627 @default.
• W1968954858 cites W2077679863 @default.
• W1968954858 cites W2089991117 @default.
• W1968954858 cites W2107202569 @default.
• W1968954858 cites W2113145432 @default.
• W1968954858 cites W2117291755 @default.
• W1968954858 cites W2150230015 @default.
• W1968954858 cites W2204433245 @default.
• W1968954858 cites W2270528790 @default.
• W1968954858 cites W2292105479 @default.
• W1968954858 cites W2396978410 @default.
• W1968954858 cites W2461630477 @default.
• W1968954858 cites W2608724752 @default.
• W1968954858 doi "https://doi.org/10.1182/blood.v98.3.781" @default.
• W1968954858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11468179" @default.
• W1968954858 hasPublicationYear "2001" @default.
• W1968954858 type Work @default.
• W1968954858 sameAs 1968954858 @default.
• W1968954858 citedByCount "58" @default.
• W1968954858 countsByYear W19689548582012 @default.
• W1968954858 countsByYear W19689548582013 @default.
• W1968954858 countsByYear W19689548582014 @default.
• W1968954858 countsByYear W19689548582016 @default.
• W1968954858 countsByYear W19689548582018 @default.
• W1968954858 countsByYear W19689548582019 @default.
• W1968954858 countsByYear W19689548582020 @default.
• W1968954858 countsByYear W19689548582021 @default.
• W1968954858 countsByYear W19689548582022 @default.
• W1968954858 crossrefType "journal-article" @default.
• W1968954858 hasAuthorship W1968954858A5016803459 @default.
• W1968954858 hasAuthorship W1968954858A5028007261 @default.
• W1968954858 hasAuthorship W1968954858A5036693524 @default.
• W1968954858 hasAuthorship W1968954858A5049503939 @default.
• W1968954858 hasAuthorship W1968954858A5066518317 @default.
• W1968954858 hasAuthorship W1968954858A5067952728 @default.
• W1968954858 hasAuthorship W1968954858A5081539801 @default.
• W1968954858 hasAuthorship W1968954858A5082847339 @default.
• W1968954858 hasAuthorship W1968954858A5088261921 @default.
• W1968954858 hasAuthorship W1968954858A5090350899 @default.
• W1968954858 hasBestOaLocation W19689548581 @default.
• W1968954858 hasConcept C104317684 @default.
• W1968954858 hasConcept C128526571 @default.
• W1968954858 hasConcept C13514818 @default.
• W1968954858 hasConcept C153911025 @default.
• W1968954858 hasConcept C159654299 @default.
• W1968954858 hasConcept C2778453870 @default.
• W1968954858 hasConcept C2778563104 @default.
• W1968954858 hasConcept C2779921676 @default.
• W1968954858 hasConcept C501734568 @default.
• W1968954858 hasConcept C54355233 @default.
• W1968954858 hasConcept C86803240 @default.
• W1968954858 hasConcept C96007430 @default.
• W1968954858 hasConcept C96926380 @default.
• W1968954858 hasConceptScore W1968954858C104317684 @default.

• next