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• W1969304814 abstract "A precise understanding of the flexibility of double stranded nucleic acids and the nature of their deformed conformations induced by external forces is important for a wide range of biological processes including transcriptional regulation, supercoil and catenane removal, and site-specific recombination. We present, at atomic resolution, a simulation of the dynamics involved in the transitions from B-DNA and A-RNA to Pauling (P) forms and to denatured states driven by application of external torque and tension. We then calculate the free energy profile along a B- to P-transition coordinate and from it, compute a reversible pathway, i.e., an isotherm of tension and torque pairs required to maintain P-DNA in equilibrium. The reversible isotherm maps correctly onto a phase diagram derived from single molecule experiments, and yields values of elongation, twist, and twist-stretch coupling in agreement with measured values. We also show that configurational entropy compensates significantly for the large electrostatic energy increase due to closer-packed P backbones. A similar set of simulations applied to RNA are used to predict a novel structure, P-RNA, with its associated free energy, equilibrium tension, torque and structural parameters, and to assign the location, on the phase-diagram, of a putative force-torque-dependent RNA triple point." @default.
• W1969304814 created "2016-06-24" @default.
• W1969304814 creator A5044070375 @default.
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• W1969304814 date "2006-10-31" @default.
• W1969304814 modified "2023-10-05" @default.
• W1969304814 title "On structural transitions, thermodynamic equilibrium, and the phase diagram of DNA and RNA duplexes under torque and tension" @default.
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• W1969304814 doi "https://doi.org/10.1073/pnas.0603850103" @default.
• W1969304814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1637560" @default.
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