FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974861666> ?p ?o ?g. }

• W1974861666 endingPage "578" @default.
• W1974861666 startingPage "569" @default.
• W1974861666 abstract "1 Acetylcholine, ionophore A23187 and melittin induced endothelium-dependent relaxations of preconstricted strips of rabbit aorta. These relaxations are likely to be mediated by endothelium-derived relaxing factor (EDRF). 2 Relaxations in response to acetylcholine (1 μm) were inhibited by the following lipoxygenase inhibitors, with the approximate IC50 values indicated in parentheses: gossypol (1.5 μm), nordi-hydroguairetic acid (NDGA, 5 μm), AA 861 (20 μm), phenidone (30 μm), quercetin (40 μm), BW 755C (300 μm), and piriprost (500 μm); with cirsiliol 50% inhibition was not achieved. Acetylcholine-induced relaxations were also blocked by the cytochrome P-450-mono-oxygenase inhibitors proadifen (SKF 525A, 4 μm), metyrapone (300 μm), and cimetidine (300 μm); 7,8 benzoflavone had no effect up to 100 μm. 3 The more potent inhibitors were also tested against relaxations induced by A23187 (0.1 μm) and melittin (1 μm) and produced partial inhibition of these relaxations. 4 The mechanism of action of the more potent inhibitors was investigated in a bioassay system. EDRF was produced in columns filled with cultured human endothelial cells. The factor was bioassayed with endothelium denuded segments of rabbit femoral artery. When added to effluent of the column, NDGA, AA861, proadifen and metyrapone inhibited the EDRF-induced vasodilatation, whereas gossypol had no effect. Gossypol, however, blocked EDRF production when infused through the column. 5 The more potent inhibitors were also tested to determine their effect on purified soluble guanylate cyclase. While gossypol, NDGA and proadifen had no appreciable effects, basal and nitroprusside (50 μm)-stimulated guanylate cyclase activity was inhibited by AA861 and metyrapone. 6 These data suggest that many of the above compounds inhibit EDRF by mechanisms other than lipoxygenase- or cytochrome P-450-mono-oxygenase inhibition." @default.
• W1974861666 created "2016-06-24" @default.
• W1974861666 creator A5049269468 @default.
• W1974861666 creator A5064206049 @default.
• W1974861666 creator A5087580516 @default.
• W1974861666 creator A5089373462 @default.
• W1974861666 date "1988-03-01" @default.
• W1974861666 modified "2023-10-15" @default.
• W1974861666 title "Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation" @default.
• W1974861666 cites W1930606978 @default.
• W1974861666 cites W1966328639 @default.
• W1974861666 cites W1978955521 @default.
• W1974861666 cites W1986305114 @default.
• W1974861666 cites W1998167871 @default.
• W1974861666 cites W2002122576 @default.
• W1974861666 cites W2002990993 @default.
• W1974861666 cites W2007737411 @default.
• W1974861666 cites W2025185754 @default.
• W1974861666 cites W2033771997 @default.
• W1974861666 cites W2038851254 @default.
• W1974861666 cites W2040185588 @default.
• W1974861666 cites W2041735424 @default.
• W1974861666 cites W2052491169 @default.
• W1974861666 cites W2054077900 @default.
• W1974861666 cites W2056343330 @default.
• W1974861666 cites W2061139907 @default.
• W1974861666 cites W2065399599 @default.
• W1974861666 cites W2067545717 @default.
• W1974861666 cites W2076583182 @default.
• W1974861666 cites W2079248207 @default.
• W1974861666 cites W2086652686 @default.
• W1974861666 cites W2090511103 @default.
• W1974861666 cites W2104413959 @default.
• W1974861666 cites W2107072266 @default.
• W1974861666 cites W2129367506 @default.
• W1974861666 cites W2130054105 @default.
• W1974861666 cites W2142975032 @default.
• W1974861666 cites W2166847791 @default.
• W1974861666 cites W2169182236 @default.
• W1974861666 cites W2175642831 @default.
• W1974861666 cites W2266589204 @default.
• W1974861666 cites W2274474673 @default.
• W1974861666 cites W2407129838 @default.
• W1974861666 cites W2483235927 @default.
• W1974861666 cites W2410496783 @default.
• W1974861666 doi "https://doi.org/10.1111/j.1476-5381.1988.tb10312.x" @default.
• W1974861666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1853851" @default.
• W1974861666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2897218" @default.
• W1974861666 hasPublicationYear "1988" @default.
• W1974861666 type Work @default.
• W1974861666 sameAs 1974861666 @default.
• W1974861666 citedByCount "49" @default.
• W1974861666 countsByYear W19748616662013 @default.
• W1974861666 crossrefType "journal-article" @default.
• W1974861666 hasAuthorship W1974861666A5049269468 @default.
• W1974861666 hasAuthorship W1974861666A5064206049 @default.
• W1974861666 hasAuthorship W1974861666A5087580516 @default.
• W1974861666 hasAuthorship W1974861666A5089373462 @default.
• W1974861666 hasBestOaLocation W19748616662 @default.
• W1974861666 hasConcept C120770815 @default.
• W1974861666 hasConcept C134018914 @default.
• W1974861666 hasConcept C170493617 @default.
• W1974861666 hasConcept C178790620 @default.
• W1974861666 hasConcept C181199279 @default.
• W1974861666 hasConcept C185592680 @default.
• W1974861666 hasConcept C202751555 @default.
• W1974861666 hasConcept C2775910092 @default.
• W1974861666 hasConcept C2776889390 @default.
• W1974861666 hasConcept C2778001312 @default.
• W1974861666 hasConcept C2779281246 @default.
• W1974861666 hasConcept C2779591629 @default.
• W1974861666 hasConcept C2779610285 @default.
• W1974861666 hasConcept C2780310817 @default.
• W1974861666 hasConcept C2780857362 @default.
• W1974861666 hasConcept C519581460 @default.
• W1974861666 hasConcept C55493867 @default.
• W1974861666 hasConcept C86803240 @default.
• W1974861666 hasConcept C98274493 @default.
• W1974861666 hasConceptScore W1974861666C120770815 @default.
• W1974861666 hasConceptScore W1974861666C134018914 @default.
• W1974861666 hasConceptScore W1974861666C170493617 @default.
• W1974861666 hasConceptScore W1974861666C178790620 @default.
• W1974861666 hasConceptScore W1974861666C181199279 @default.
• W1974861666 hasConceptScore W1974861666C185592680 @default.
• W1974861666 hasConceptScore W1974861666C202751555 @default.
• W1974861666 hasConceptScore W1974861666C2775910092 @default.
• W1974861666 hasConceptScore W1974861666C2776889390 @default.
• W1974861666 hasConceptScore W1974861666C2778001312 @default.
• W1974861666 hasConceptScore W1974861666C2779281246 @default.
• W1974861666 hasConceptScore W1974861666C2779591629 @default.
• W1974861666 hasConceptScore W1974861666C2779610285 @default.
• W1974861666 hasConceptScore W1974861666C2780310817 @default.
• W1974861666 hasConceptScore W1974861666C2780857362 @default.
• W1974861666 hasConceptScore W1974861666C519581460 @default.
• W1974861666 hasConceptScore W1974861666C55493867 @default.
• W1974861666 hasConceptScore W1974861666C86803240 @default.
• W1974861666 hasConceptScore W1974861666C98274493 @default.
• W1974861666 hasIssue "3" @default.

• next