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- W1976919957 abstract "Cognitive side effects of systemic chemotherapy have become an increasing concern among breast cancer survivors, their families, and health care professionals. A growing body of research supports the hypothesis that chemotherapy can produce long-term cognitive changes in at least a subgroup of cancer survivors. We review evidence implicating systemic chemotherapy as the cause of cognitive changes; describe the limitations due to lack of longitudinal studies and gaps in knowledge (ie, no clear mechanism by which chemotherapy can produce cognitive changes has been proposed); discuss possible factors like age, intelligence quotient/education, and psychological, genetic, and hormonal factors that might increase risk for chemotherapy-induced cognitive changes; and outline future directions for research. Such future research includes large-scale, longitudinal studies of pretreatment neuropsychological assessments, use of imaging techniques and the development of animal models to study the mechanisms of chemotherapy-induced changes in cognitive functioning, and the development of interventions to prevent or reduce the negative cognitive effects of chemotherapy." @default.
- W1976919957 created "2016-06-24" @default.
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- W1976919957 date "2002-12-01" @default.
- W1976919957 modified "2023-10-16" @default.
- W1976919957 title "Breast Cancer Chemotherapy-Related Cognitive Dysfunction" @default.
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- W1976919957 doi "https://doi.org/10.3816/cbc.2002.s.018" @default.
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