FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977573492> ?p ?o ?g. }

• W1977573492 endingPage "841" @default.
• W1977573492 startingPage "831" @default.
• W1977573492 abstract "An allele of the human dopamine D4 receptor (D4R) gene (DRD4), containing seven tandem repeats of a 48-base nucleotide sequence (DRD4.7), has been reproducibly found in novelty seekers, substance abusers, and individuals with attention-deficit hyperactivity disorder. One hypothesis predicts the resultant protein product of the DRD4.7 polymorphism is deficient in G protein-coupled signaling. If attenuated D4R signaling contributes to these complex behaviors, then wild-type (WT) mice and mice completely lacking D4Rs (D4R KO) might be expected to display significantly different behavioral responses to stimuli known to affect dopamine signaling, such as novelty or psychostimulants. Adolescent male D4R KO mice exhibited greater locomotor activity and spent less time in the anxiogenic center of a novel open field environment than WT littermates. The presence of D4Rs had no effect on emergence into a novel environment from a sheltered space or exploration of a novel object. Low doses of acute methylphenidate (MP) had no effect on the exploration of a novel object, but dose-dependently increased the latency to emerge into a novel environment from a sheltered space. WT and D4R KO mice responded differently to high doses of acute MP, displaying significantly elevated locomotor activity and reduced stereotypy relative to WT mice. Chronic MP treatment produced enhanced locomotor sensitization in D4R KO mice, however this effect could not be fully recapitulated using the putative D4R antagonist L-745-870. These studies suggest that the roles of D4R signaling in novelty-seeking behaviors and the response to psychostimulants are not as clear as previously reported, and that some of these effects may be due to developmental compensatory effects as a consequence of lost D4R expression. If the DRD4.7 variant results in deficient D4R signaling in vivo, this may contribute to an elevated risk of sensitization to drugs of abuse including psychostimulants used to treat ADHD." @default.
• W1977573492 created "2016-06-24" @default.
• W1977573492 creator A5010962738 @default.
• W1977573492 creator A5013305898 @default.
• W1977573492 creator A5025223309 @default.
• W1977573492 creator A5067184628 @default.
• W1977573492 date "2013-02-01" @default.
• W1977573492 modified "2023-10-05" @default.
• W1977573492 title "Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate" @default.
• W1977573492 cites W1513017963 @default.
• W1977573492 cites W1846887479 @default.
• W1977573492 cites W1867555087 @default.
• W1977573492 cites W1965775294 @default.
• W1977573492 cites W1966137409 @default.
• W1977573492 cites W1969579537 @default.
• W1977573492 cites W1971671044 @default.
• W1977573492 cites W1973678939 @default.
• W1977573492 cites W1975977959 @default.
• W1977573492 cites W1977277286 @default.
• W1977573492 cites W1978443369 @default.
• W1977573492 cites W1979430972 @default.
• W1977573492 cites W1981664395 @default.
• W1977573492 cites W1986475800 @default.
• W1977573492 cites W1991899916 @default.
• W1977573492 cites W1992246230 @default.
• W1977573492 cites W1994436062 @default.
• W1977573492 cites W1994956163 @default.
• W1977573492 cites W1998147949 @default.
• W1977573492 cites W2007018336 @default.
• W1977573492 cites W2015176102 @default.
• W1977573492 cites W2016578771 @default.
• W1977573492 cites W2017529663 @default.
• W1977573492 cites W2017999341 @default.
• W1977573492 cites W2018579585 @default.
• W1977573492 cites W2026395566 @default.
• W1977573492 cites W2028703797 @default.
• W1977573492 cites W2034607657 @default.
• W1977573492 cites W2044688560 @default.
• W1977573492 cites W2050283568 @default.
• W1977573492 cites W2051315778 @default.
• W1977573492 cites W2053220357 @default.
• W1977573492 cites W2053529553 @default.
• W1977573492 cites W2054251181 @default.
• W1977573492 cites W2059124791 @default.
• W1977573492 cites W2059230444 @default.
• W1977573492 cites W2062704469 @default.
• W1977573492 cites W2067587687 @default.
• W1977573492 cites W2068057675 @default.
• W1977573492 cites W2069715147 @default.
• W1977573492 cites W2077614189 @default.
• W1977573492 cites W2087683500 @default.
• W1977573492 cites W2103124605 @default.
• W1977573492 cites W2104320913 @default.
• W1977573492 cites W2105591658 @default.
• W1977573492 cites W2106862702 @default.
• W1977573492 cites W2117184058 @default.
• W1977573492 cites W2118774378 @default.
• W1977573492 cites W2120981636 @default.
• W1977573492 cites W2122592499 @default.
• W1977573492 cites W2126701473 @default.
• W1977573492 cites W2129176481 @default.
• W1977573492 cites W2134295579 @default.
• W1977573492 cites W2141419779 @default.
• W1977573492 cites W2143863602 @default.
• W1977573492 cites W2146709629 @default.
• W1977573492 cites W2147177339 @default.
• W1977573492 cites W2154264553 @default.
• W1977573492 cites W2168722817 @default.
• W1977573492 cites W2176056137 @default.
• W1977573492 doi "https://doi.org/10.1016/j.pbb.2012.12.006" @default.
• W1977573492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23262298" @default.
• W1977573492 hasPublicationYear "2013" @default.
• W1977573492 type Work @default.
• W1977573492 sameAs 1977573492 @default.
• W1977573492 citedByCount "19" @default.
• W1977573492 countsByYear W19775734922013 @default.
• W1977573492 countsByYear W19775734922014 @default.
• W1977573492 countsByYear W19775734922015 @default.
• W1977573492 countsByYear W19775734922016 @default.
• W1977573492 countsByYear W19775734922017 @default.
• W1977573492 countsByYear W19775734922019 @default.
• W1977573492 countsByYear W19775734922020 @default.
• W1977573492 countsByYear W19775734922021 @default.
• W1977573492 crossrefType "journal-article" @default.
• W1977573492 hasAuthorship W1977573492A5010962738 @default.
• W1977573492 hasAuthorship W1977573492A5013305898 @default.
• W1977573492 hasAuthorship W1977573492A5025223309 @default.
• W1977573492 hasAuthorship W1977573492A5067184628 @default.
• W1977573492 hasConcept C118552586 @default.
• W1977573492 hasConcept C126322002 @default.
• W1977573492 hasConcept C134018914 @default.
• W1977573492 hasConcept C137183658 @default.
• W1977573492 hasConcept C15744967 @default.
• W1977573492 hasConcept C169760540 @default.
• W1977573492 hasConcept C170493617 @default.
• W1977573492 hasConcept C205044023 @default.
• W1977573492 hasConcept C2776217527 @default.
• W1977573492 hasConcept C2776755682 @default.

• next